Journal of Periodontal and Implant Science
- Volume 31 Issue 4
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- Pages.661-668
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- 2001
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- 2093-2278(pISSN)
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- 2093-2286(eISSN)
Fusobacterium nucleatum modulates serum binding to Porphyromonas gingivalis biofilm
Porphyromonas gingivalis biofilm에 대한 면역혈청의 침투력에 대한 Fusobacterium nucleatum의 조절효과
- Choi, Jeom-Il (Department of Periodontology, School of Dentistry, Pusan National University) ;
- Kim, Sung-Jo (Department of Periodontology, School of Dentistry, Pusan National University) ;
- Kim, Soo-Jin (Department of Periodontology, School of Dentistry, Pusan National University)
- Published : 2001.12.31
Abstract
Anti-P. gingivalis immune sera were obtained from mice immunized with either P. gingivalis alone, or F. nucleaturm followed by P. gingivalis. Two groups of immune sera were examined for binding capacity to P. gingivalis biofilm by confocal laser scanning microscope, Antibody avidity index was also determined for each immune sera. The results indicated that prior immunization of mice with F. nucleaturm impaired P. gingivalis-specific immune sera in binding capacity to biofilm and antibody avidity to P. gingivalis. Elevated antibody responses in patients with destructive periodontal disease has often been related to suboptimal level of protective antibody
P. gingivalis를 단독면역하거나 또는 Fusobacterium nucleatum 선면역 후 P. gingivalis 항혈청을 각각 얻어냈다. 두 종류의 항혈청이 P. gingivalis biofilm을 침투해 들어가는 능력을 confocal laser scanning microscope를 이용하여 비교 감증하였다. 항혈청의 P. gingivalis에 대한 avidity index도 측정하였다. 결과적으로 F. nucleatum의 선면역은 P. gingivalis 특이 항혈청에 대해 세균성 biofilm의 침투능력을 저하시키고, 동일한 세균에 대한 avidity도 감소시켰다.