Journal of Periodontal and Implant Science
- 제31권3호
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- Pages.597-610
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- 2001
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- 2093-2278(pISSN)
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- 2093-2286(eISSN)
니코틴이 치은섬유아세포의 세포주기 조절 단백질 발현에 미치는 영향
Effects of Nicotine on the Expression of Cell Cycle Regulatory Proteins of Human Gingival Fibroblasts
- 김탁 (원광대학교 치과대학 치주과학교실) ;
- 김재호 (원광대학교 치과대학 치주과학교실) ;
- 피성희 (원광대학교 치과대학 치주과학교실) ;
- 김은철 (원광대학교 치과대학 구강병리학교실) ;
- 유용욱 (원광대학교 치과대학 구강생화학교실) ;
- 유형근 (원광대학교 치과대학 치주과학교실) ;
- 신형식 (원광대학교 치과대학 치주과학교실)
- Kim, Tak (Department of Periodontology, School of Dentistry, Wonkwang University) ;
- Kim, Jae-ho (Department of Periodontology, School of Dentistry, Wonkwang University) ;
- Pi, Sung-Hee (Department of Periodontology, School of Dentistry, Wonkwang University) ;
- Kim, Eun-Cheol (Department of Oral Pathology, School of Dentistry, Wonkwang University) ;
- You, Yong-Ouk (Department of Oral Biochemistry, School of Dentistry, Wonkwang University) ;
- You, Hyung-Keun (Department of Periodontology, School of Dentistry, Wonkwang University) ;
- Shin, Hyung-Shik (Department of Periodontology, School of Dentistry, Wonkwang University)
- 발행 : 2001.09.30
초록
Normal gingival fibroblasts functioning is fundamental for the maintenance of periodontal connective tissue as well as wound healing. Nicotine have been found to affect DNA synthesis and cell proliferation, which appear to depend on the type of cells. This in vitro study was done to determine the effects of nicotine, a major component of tobacco, on cell proliferation, viability, activity, cell cycle distribution, and expression of cell cycle regulatory proteins in human gingival fibroblasts. Nicotine has been tested for 2 days or 4 days in 5 different concentrations;