Journal of Periodontal and Implant Science
- Volume 31 Issue 2
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- Pages.371-388
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- 2001
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- 2093-2278(pISSN)
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- 2093-2286(eISSN)
A Clinical Trial of Dextranase-Containing Mouthwash on the Inhibition of Plaque Formation and Gingivitis
Dextranase 함유 구강 세정액의 치태 억제 및 치은염 예방 효과에 관한 임상적 연구
- Song, Woo-Sung (Department of Periodontology, College of Dentistry and Dental Science Research Institute, Chonnam National University) ;
- Son, Eun-Ju (Department of Periodontology, College of Dentistry and Dental Science Research Institute, Chonnam National University) ;
- Kim, Do-Man (Department of Biochemical Engineering, College of Engineering, Chonnam National University) ;
- Chung, Hyun-Ju (Department of Periodontology, College of Dentistry and Dental Science Research Institute, Chonnam National University)
- 송우성 (전남대학교 치과대학 치주과학교실 및 치의학연구소) ;
- 손은주 (전남대학교 치과대학 치주과학교실 및 치의학연구소) ;
- 김도만 (전남대학교 공과대학 생물화공과) ;
- 정현주 (전남대학교 치과대학 치주과학교실 및 치의학연구소)
- Published : 2001.06.30
Abstract
A novel glucanhydrolase(DXAMase) from a mutant of Lipomyces starkeyi(KSM 22) has been shown effective in hydrolysis of mutan, reduction of mutan formation by Streptococcus mutans and removal pre-formed sucrose-dependentadherent microbial film and DXAMase has been strongly bound to hydroxyapatitie. These in vitro properties of Lipomyces starkeyi DXAMase are desirable for its application as a dental plaque control agent. This study was performed to determine the adjunctive oral hygiene benefits and safety of dextranase(Lipomyces starkeyi KSM 22 DXAMase)-containing mouthwash when used alongside normal tooth-brushing. This 6-month clinical trial was placebo-controlled double-blind design evaluating 1U/ml dextranase mouthwash and 0.12% chlorhexidine mouthwash. A total 39 systemically healthy subjects, who had moderate levels of plaque and gingivitis were included. At baseline, 1, 3 and 6 months, subjects were scored for plaque accumulation(Turesky modification of Quingley-Hein's plaque index), gingivitis status(
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