Journal of Periodontal and Implant Science
- Volume 31 Issue 2
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- Pages.299-315
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- 2001
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- 2093-2278(pISSN)
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- 2093-2286(eISSN)
Effects of Tetracycline-loaded Poly(L-lactide) Barrier Membranes on Guided Bone Regeneration in Beagle Dog
테트라싸이클린 함유 차폐막을 이용한 골조직 유도 재생에 관한 연구
- Choi, Kwang-Soo (Department of Periodontology, School of Dentistry, Wonkwang University) ;
- Kim, Tak (Department of Periodontology, School of Dentistry, Wonkwang University) ;
- Yang, Dae-Seung (Department of Periodontology, School of Dentistry, Wonkwang University) ;
- Kim, Eun-Cheol (Department of Oral Pathology, School of Dentistry, Wonkwang University) ;
- You, Hyung-Keun (Department of Periodontology, School of Dentistry, Wonkwang University) ;
- Shin, Hyung-Shik (Department of Periodontology, School of Dentistry, Wonkwang University)
- 최광수 (원광대학교 치과대학 치주과학교실) ;
- 김탁 (원광대학교 치과대학 치주과학교실) ;
- 양대승 (원광대학교 치과대학 치주과학교실) ;
- 김은철 (원광대학교 치과대학 구강병리학교실) ;
- 유형근 (원광대학교 치과대학 치주과학교실) ;
- 신형식 (원광대학교 치과대학 치주과학교실)
- Published : 2001.06.30
Abstract
Application of membranes for guided tissue regeneration(GTR) have been confined to the subgingival barrier functions; however, many studies have provided evidence that some drugs, including tetracycline, initially can promote the growth of periodontal ligament or alveolar bone in peridontal therapy. Osseous regeneration in periodontal defects is increased by local administration of tetracycline due to its anti-collagenolytic effect, which enhances bone-forming ability via osteoblast cell chemotaxis and reduced bone resorption. The aim of this study was to evaluate effects of tetracycline loaded poly-L-lactide(PLLA) barrier membranes for guided bone regenerative potential. Tetracycline was incorporated into the PLLA membrane with the ratio 10% to PLLA by weight. Ability to guided bone regeneration of the membranes were tested by measuring new bone in the tibial defects(