Journal of Periodontal and Implant Science
- Volume 31 Issue 1
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- Pages.179-193
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- 2001
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- 2093-2278(pISSN)
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- 2093-2286(eISSN)
Effect of Bisphosphonate on Osteoblastic Activity of the Human Periodontal Ligament Cells in Vitro
Bisphosphonate가 배양된 치주인대세포의 조골작용에 미치는 효과
- Kim, Eun-Young (Dept. of Periodontology, College of Dentistry, Research Institute of Dental Science Chonnam National University) ;
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Kim, Ok-Su
(Dept. of Periodontology, College of Dentistry, Research Institute of Dental Science Chonnam National University) ;
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Chung, Hyun-Ju
(Dept. of Periodontology, College of Dentistry, Research Institute of Dental Science Chonnam National University)
- 김은영 (전남대학교 치과대학 치주과학교실 및 치의학 연구소) ;
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김옥수
(전남대학교 치과대학 치주과학교실 및 치의학 연구소) ;
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정현주
(전남대학교 치과대학 치주과학교실 및 치의학 연구소)
- Published : 2001.03.30
Abstract
previous studies have demonstrated an increase in bone mass and density with use of bisphosphonate in osteoporosis. This agent acts as an inhibitor of osteoclastic activity and results in increase of net osteoblastic activity. The purpose of the present study was to examine the effect of the bisphosphonate on osteoblastic activity of the human periodontal ligament cells in vitro. Periodontal ligament cells were primarily obtained from extracted healthy third molars. Cells of 4th to 6th passage were cultured in Dulbecco's modified Eagle's medium containing alendronate sodium or etidronate disodium at the concentration of
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