Journal of Periodontal and Implant Science
- 제31권1호
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- Pages.1-23
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- 2001
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- 2093-2278(pISSN)
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- 2093-2286(eISSN)
혈소판유래성장인자를 함유한 Chitosan/Calcium Metaphosphate의 골조직재생효과에 관한 연구
The Effect of Platelet Derived Growth Factor - BB Loaded Chitosan/Calcium Metaphosphate on Bone Regeneration
- 이승열 (서울대학교 치과대학 치주과학교실 및 치학연구소) ;
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설양조
(서울대학교 치과대학 치주과학교실 및 치학연구소, 성균관대학교 의과대학 치과학교실) ;
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이용무
(서울대학교 치과대학 치주과학교실 및 치학연구소) ;
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이주연
(이화여자대학교 약학대학 물리약학교실) ;
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이승진
(이화여자대학교 약학대학 물리약학교실) ;
- 김석영 (영남대학교 공과대학 재료금속공학부) ;
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구영
(서울대학교 치과대학 치주과학교실 및 치학연구소) ;
- 류인철 (서울대학교 치과대학 치주과학교실 및 치학연구소) ;
- 한수부 (서울대학교 치과대학 치주과학교실 및 치학연구소) ;
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최상묵
(서울대학교 치과대학 치주과학교실 및 치학연구소) ;
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정종평
(서울대학교 치과대학 치주과학교실 및 치학연구소)
- Lee, Seung-Yeol (Department of Periodontology and Dental Research Institute, College of Dentistry, Seoul National University) ;
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Seol, Yang-Jo
(Department of Periodontology and Dental Research Institute, College of Dentistry, Seoul National University, Department of Dentistry, College of Medicine, Sungkyunkwan University) ;
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Lee, Yong-Moo
(Department of Periodontology and Dental Research Institute, College of Dentistry, Seoul National University) ;
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Lee, Ju-Yeon
(Department Industrial Pharmacy, College of Pharmacy, Ewha Womans University) ;
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Lee, Seung-Jin
(Department Industrial Pharmacy, College of Pharmacy, Ewha Womans University) ;
- Kim, Suk-Young (School of Materials and Metal Engineering, College of Engineering Yeungnam University) ;
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Ku, Young
(Department of Periodontology and Dental Research Institute, College of Dentistry, Seoul National University) ;
- Rhyu, In-Chul (Department of Periodontology and Dental Research Institute, College of Dentistry, Seoul National University) ;
- Han, Soo-Boo (Department of Periodontology and Dental Research Institute, College of Dentistry, Seoul National University) ;
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Choi, Sang-Mook
(Department of Periodontology and Dental Research Institute, College of Dentistry, Seoul National University) ;
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Chung, Chong-Pyoung
(Department of Periodontology and Dental Research Institute, College of Dentistry, Seoul National University)
- 발행 : 2001.03.30
초록
Chitosan is biodegradable natural polymer that has been demonstrated its ability to improve wound healing, and calcium metaphosphate(CMP) is a unique class of phosphate minerals having a polymeric structure. In this study, chitosan/CMP and platelet derived growth factor(PDGF-BB) loaded chitosan/CMP sponges were developed, and the effect of the sponges on bone regeneration and their possibility as scaffolds for bone formation by three-dimensional osteoblast culture were examined. PDGF-BB loaded chitosan/CMP sponges were prepared by freeze-drying of a mixture of chitosan solution and CMP powder, and soaking in a PDGF-BB solution. Fabricated sponge retained its 3-dimensional porous structure with
키워드