Korean Journal of Radiology

The Korean Society of Radiology (대한영상의학회)
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Detection of Malignant Primary Hepatic Neoplasms with Gadobenate Dimeglumine (Gd-BOPTA) Enhanced T1-Weighted Hepatocyte Phase MR Imaging: Results of Off-site Blinded Review in a Phase-II Multicenter Trial

  • Constantino S. Pena (Division of Abdominal Imaging and Intervention, Department of Radiology, Massachusetts General Hospital and Harvard Medical School) ;
  • Sanjay Saini (Division of Abdominal Imaging and Intervention, Department of Radiology, Massachusetts General Hospital and Harvard Medical School) ;
  • Richard L. Baron (Department of Radiology, University of Pittsburgh) ;
  • Bernd A. Hamm (Department of Radiology, Charite Charite Hospital, Humboldt University) ;
  • Giovanni Morana (Istituto di Radiologia, Policlinico di Borgo Roma) ;
  • Roberto Caudana (Istituto di Radiologia, Policlinico di Borgo Roma) ;
  • Andrea Giovagnoni (Dipartimento di Scienze Mediche, Oncologiche e Radiologiche, Universita degli Studi di Modena e Reggio Emilia) ;
  • Andrea Villa (Istituto di Radiologia, Policlinico San Matteo) ;
  • Alessandro Carriero (Istituto di Scienze Radiologiche e Formazione dell'Imagine, Ospedale Santissima Annunziata) ;
  • Didier Mathieu (Service de Radiologie, Hopital Henri Mondor) ;
  • Michael W. Bourne (Department of Diagnostic Radiology, University Hospital of Wales) ;
  • Miles A. Kirchin (Medical and Regulatory Affairs, Bracco SpA) ;
  • Gianpaolo Pirovano (Medical and Regulatory Affairs, Bracco SpA) ;
  • Alberto Spinazzi (Medical and Regulatory Affairs, Bracco SpA)
  • Received : 2001.04.02
  • Accepted : 2001.09.05
  • Published : 2001.12.31
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Abstract

Objective: To investigate the efficacy of gadobenate dimeglumine (GdBOPTA) enhanced MR imaging for the detection of liver lesions in patients with primary malignant hepatic neoplasms. Materials and Methods: Thirty-one patients with histologically proven primary malignancy of the liver were evaluated before and after administration of GdBOPTA at dose 0.05 or 0.10 mmol/kg. T1-weighted spin echo (T1W-SE) and gradient echo (T1W-GRE) images were evaluated for lesion number, location, size and confidence by three off-site independent reviewers and the findings were compared to reference standard imaging (intraoperative ultrasound, computed tomography during arterial portography or lipiodol computed tomography). Results were analyzed for significance using a two-sided McNemar's test. Results: More lesions were identified on Gd-BOPTA enhanced images than on unenhanced images and there was no significant difference in lesion detection between either concentration. The largest benefit was in detection of lesions under 1 cm in size (7 to 21, 9 to 15, 16 to 18 for reviewers A, B, C respectively). In 68% of the patients with more than one lesion, Gd-BOPTA increased the number of lesions detected. Conclusion: Liver MR imaging after Gd-BOPTA increases the detection of liver lesions in patients with primary malignant hepatic neoplasm.

Keywords

References

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