Korean Journal of Radiology

  • 제2권4호
  • /
  • Pages.192-196
  • /
  • 2001
  • /
  • 1229-6929(pISSN)
  • /
  • 2005-8330(eISSN)
대한영상의학회 (The Korean Society of Radiology)
권호 표지

Diffusion-Weighted MR Imaging in Biopsy-Proven Creutzfeldt-Jakob Disease

  • Hyo-Cheol Kim (Department of Radiology, Seoul National University College of Medicine, and Institute of Radiation Medicine, SNUMRC) ;
  • Kee-Hyun Chang (Department of Radiology, Seoul National University College of Medicine, and Institute of Radiation Medicine, SNUMRC) ;
  • In Chan Song (Department of Radiology, Seoul National University College of Medicine, and Institute of Radiation Medicine, SNUMRC) ;
  • Sang Hyun Lee (Department of Radiology, Seoul National University College of Medicine, and Institute of Radiation Medicine, SNUMRC) ;
  • Bae Ju Kwon (Department of Radiology, Seoul National University College of Medicine, and Institute of Radiation Medicine, SNUMRC) ;
  • Moon Hee Han (Department of Radiology, Seoul National University College of Medicine, and Institute of Radiation Medicine, SNUMRC) ;
  • Sang-Yun Kim (Department of Neurology, Seoul National University College of Medicine)
  • 투고 : 2001.05.29
  • 심사 : 2001.09.08
  • 발행 : 2001.12.31
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초록

Objective: To compare conventional and diffusion-weighted MR imaging in terms of their depiction of the abnormalities occurring in Creutzfeldt-Jakob disease. Materials and Methods: We retrospectively analyzed the findings of conventional (T2-weighted and fluid-attenuated inversion recovery) and diffusion-weighted MR imaging in four patients with biopsy-proven Creutzfeldt-Jakob disease. The signal intensity of the lesion was classified by visual assessment as markedly high, slightly high, or isointense, relative to normal brain parenchyma. Results: Both conventional and diffusion-weighted MR images demonstrated bilateral high signal intensity in the basal ganglia in all four patients. Cortical lesions were observed on diffusion-weighted MR images in all four, and on fluid-attenuated inversion recovery MR images in one, but in no patient on T2-weighted images. Conventional MR images showed slightly high signal intensity in all lesions, while diffusion-weighted images showed markedly high signal intensity in most. Conclusion: Diffusion-weighted MR imaging is more sensitive than its conventional counterpart in the depiction of Creutzfeldt-Jakob disease, and permits better detection of the lesion in both the cerebral cortices and basal ganglia.

키워드

과제정보

This study was supported in part by the 2001 BK21 Project for Medicine, Dentistry, and Pharmacy.

참고문헌

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