Korean Journal of Radiology

  • 제2권1호
  • /
  • Pages.21-27
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  • 2001
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  • 1229-6929(pISSN)
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  • 2005-8330(eISSN)
대한영상의학회 (The Korean Society of Radiology)
권호 표지

Evaluation by Contrast-Enhanced MR Imaging of the Lateral Border Zone in Reperfused Myocardial Infarction in a Cat Model

  • Ae Kyung Jeong (Department of Diagnostic Radiology, Asan Medical Center, University of Ulsan College of Medicine) ;
  • Sang Il Choi (Department of Diagnostic Radiology, Asan Medical Center, University of Ulsan College of Medicine) ;
  • Dong Hun Kim (Department of Diagnostic Radiology, Asan Medical Center, University of Ulsan College of Medicine) ;
  • Sung Bin Park (Department of Diagnostic Radiology, Asan Medical Center, University of Ulsan College of Medicine) ;
  • Seoung Soo Lee (Department of Diagnostic Radiology, Asan Medical Center, University of Ulsan College of Medicine) ;
  • Seong Hoon Choi (Department of Diagnostic Radiology, Asan Medical Center, University of Ulsan College of Medicine) ;
  • Tae-Hwan Lim (Department of Diagnostic Radiology, Asan Medical Center, University of Ulsan College of Medicine)
  • 투고 : 2000.06.21
  • 심사 : 2000.12.07
  • 발행 : 2001.03.31
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초록

Objective: To identify and evaluate the lateral border zone by comparing the size and distribution of the abnormal signal area demonstrated by MR imaging with the infarct area revealed by pathological examination in a reperfused myocardial infarction cat model. Materials and Methods: In eight cats, the left anterior descending coronary artery was occluded for 90 minutes, and this was followed by 90 minutes of reperfusion. ECG-triggered breath-hold turbo spin-echo T2-weighted MR images were initially obtained along the short axis of the heart before the administration of contrast media. After the injection of Gadomer-17 and Gadophrin-2, contrast-enhanced T1-weighted MR images were obtained for three hours. The size of the abnormal signal area seen on each image was compared with that of the infarct area after TTC staining. To assess ultrastructural changes in the myocardium at the infarct area, lateral border zone and normal myocardium, electron microscopic examination was performed. Results: The high signal area seen on T2-weighted images and the enhanced area seen on Gadomer-17-enhanced T1WI were larger than the enhanced area on Gadophrin-2-enhanced T1WI and the infarct area revealed by TTC staining; the difference was expressed as a percentage of the size of the total left ventricle mass (T2= 39.2 %; Gadomer-17 =37.25 % vs Gadophrin-2 = 29.6 %; TTC staining = 28.2 %; p < 0.05). The ultrastructural changes seen at the lateral border zone were compatible with reversible myocardial damage. Conclusion: In a reperfused myocardial infarction cat model, the presence and size of the lateral border zone can be determined by means of Gadomer-17- and Gadophrin-2-enhanced MR imaging.

키워드

과제정보

The authors wish to thank Chung-Hwan Lim, BS, Department of Radiology, Asan Medical Center, for his technical assistance in conducting MRI with animals, and Schering A.G., Berlin, Germany, for providing Gadophrin-2 and Gadomer-17.

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