The Journal of Korean Physical Therapy

The Korean Society of Physical Therapy (대한물리치료학회)
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The Effect of Therapeutic Exercise on Brain-Derived Neurotrophic Factor After Global Brain Ischemia in Rats

흰쥐의 전뇌허혈 후 재관류 시 운동치료에 의한 신경영양성인자 발현

  • Gu, Sang-Hun (Department of Physical Therapy, Tajeon Seogu Health Center) ;
  • Song, Ju-Young (Major in Physical Therapy, Department of Rehabilitation Science, Graduate School, Taegu University) ;
  • Kown, Young-Shil (Major in Physical Therapy, Department of Rehabilitation Science, Graduate School, Taegu University) ;
  • Nam, Ki-Won (Major in Physical Therapy, Department of Rehabilitation Science, Graduate School, Taegu University) ;
  • Song, Ju-Min (Major in Physical Therapy, Department of Rehabilitation Science, Graduate School, Taegu University) ;
  • Lee, Yun-Seob (Major in Physical Therapy, Department of Rehabilitation Science, Graduate School, Taegu University) ;
  • Choi, Jin-Ho (Department of Physical Therapy, Yeongdong Junior College) ;
  • Kim, Jin-Sang (Department of Physical Therapy, College of Rehabilitation Science, Taegu University)
  • 구상훈 (대전 서구보건소 물리치료실) ;
  • 송주영 (대구대학교 대학원 재활과학과 물리치료) ;
  • 권영실 (대구대학교 대학원 재활과학과 물리치료) ;
  • 남기원 (대구대학교 대학원 재활과학과 물리치료) ;
  • 송주민 (대구대학교 대학원 재활과학과 물리치료) ;
  • 이윤섭 (대구대학교 대학원 재활과학과 물리치료) ;
  • 최진호 (영동전문대학 물리치료과) ;
  • 김진상 (대구대학교 재활과학대학 물리치료학과)
  • Published : 2001.09.24
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Abstract

This study was performed to investigate the effect of therapeutic exercise on brain-derived neurotrophic factor manifestation after global brain ischemia in rats. Nine rats with global ischemia were divided at random into two group. In the control group, three rats remained in cage. But, in the end, two rats were alive. In the therapeutic exercise group, six rats remained. The five rats of this group was swam for 30 minutes everyday for a week. The brain-derived neurotrophic factor expression was identified from immunohistochemistry. The results of this study were as follows : 1. In the control group, a little expression of brain-derived neurotrophic factor was observed at cortex and hippocampus layer, but cell body and axon was observed obscurely. 2. In the experimental group, a much expression of brain-derived neurotrophic factor was observed at cortex and hippocampus layer, and cell body and axon was observed clearly. In the neurological examination(beam-walking test). experimental group was obtained higher 1.4 points than control group. BDNF expression was increased by swimming for 30 minutes everyday for a week. Therefore, therapeutic exercise contribute to brain plasticity after brain ischemia.

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