Maxillofacial Plastic and Reconstructive Surgery

Korean Association of Maxillofacial Plastic and Reconstructive Surgeons (대한악안면성형재건외과학회)
권호 표지

THE HISTOLOGICAL AND IMMUNOHISTOCHEMICAL FINDINGS OF THE NEWLY FORMED HUMAN BONE AFTER DISTRACTION OSTEOGENESIS

하악골 신연술 후 생성된 신생골의 조직학적 및 면역화학적 소견

  • Yun, Kyoung-In (Dept. of Oral and Maxillofacial Surgery, Eul Ji Hospital, Eul Ji University, The School of Medicine) ;
  • Park, Je-Uk (Dept. of Oral and Maxillofacial Surgery, Kangnam St. Mary' s Hospital, The Catholic University of Korea)
  • 윤경인 (을지의과대학교 치과학교실 을지병원 구강악안면외과) ;
  • 박재억 (가톨릭대학교 의과대학 치과학교실 강남성모병원 구강악안면외과)
  • Published : 2001.06.30
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Abstract

Distraction osteogenesis(DO) can be performed in the bony defect associated with trauma, anomaly, and various kinds of disease. The gap generated by DO is filled with growing callus : during the period of distraction, the osteogenesis is continued. However, there have been few reports about expression pattern of growth factors in newly formed bone during the consolidation periods. We performed DO in the mandibular defect case and studied the expressed pattern of growth factors. Its pattern was compared to that of the same patient. BMP-2 and -4 were strongly expressed in the DO site. Particularly, BMP-4 was not expressed in the normal mature bone, but expressed in new bone in DO. However, there was no difference in the FGF-7 expression between the sites. Therefore, strong expression of BMP-4 are related to new bone formation in DO and they may not be related to the normal homeostasis in human bone. Though FGF-7 is related to the growth of keratinocyte, it may have minimal role in the DO and normal mature bone.

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