Determination of Mefenamic Acid with Fe(II)-Dipyridyl-Mefenamic Acid Ternary Complex as Ion-exchagner

철-디피리딜-메페남산 삼원착물을 이용한 메페남산의 정량

  • Nam, Su Ja (Department of Pharmacy, Kyungsung University) ;
  • Moon, Hyun Sook (Department of Pharmacy, Kyungsung University) ;
  • Lee, Mi Na (Department of Pharmacy, Kyungsung University) ;
  • Jung, Moon Mo (Department of Pharmacy, Kyungsung University) ;
  • Hur, Moon Hye (Pusan Regional Food & Drug Administration) ;
  • Ahn, Moon Kyu (Department of Pharmacy, Kyungsung University)
  • Received : 2000.12.21
  • Published : 2001.02.25

Abstract

A PVC membrane electrodes based on Fe(II)-dipyridyl-mefenamic acid ternary complex as ion exchanger were prepared using o-nitrophenyl octyl ether as a plasticizer. The 2,2'-dipyridyl, 4,4'-dipyridyl and 4,4'-dipyridyl-2,2'-dipyridyl were used as dipyridyl derivative ligand. The electrode dxhibits a fast stable and linear response for $10^{-5}-10^{-3}mol/L$ mefenamate with an anionic slope of -55.98, -49.47, -59.35mV/decade in pH 8.9 borate buffer solution respectively. Potentiometric selectivity measurements revealed negligible interferences from aromatic and aliphatic carboxylic acid salts.

철-디피리딜-메페남산 삼원착물을 이온교환체로, NPOE(o-nitrophenyl octyl ether)를 가소게, PVC[poly(vinyl chloride)]를 지지체로 사용한 메페남산 이온선택성막 전극을 제작하였다. 디피리딜 화합물은 2,2'-디피리딜, 4,4'-디피리딜 그리고 4,4'-디페닐-2,2'-디피리딜을 이용하였다. 이들 막전극은 pH 8.9의 붕산완충액 중에서 $10^{-5}{\sim}10^{-3}mol/L$ 농도의 메페남산에 대하여 감응전위가 -55.98, -49.47 그리고 -59.35mV/decade를 각각 나타내는 직선성이었다. 방향족 및 지방족 카복실산염의 존재는 전극의 감응에 지장을 주지 않았다.

Keywords

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