Mycobiology

The Korean Society of Mycology (한국균학회)
권호 표지

Cytotoxicity of Paecilomyces tenuipes Against Human Carcinoma Cells, HepG2 and MCF-7 In Vitro

  • Shim, Joong-Sup (Department of Biology, College of Natural Science, Dongguk University) ;
  • Chang, Hae-Ryong (Department of Biology, College of Natural Science, Dongguk University) ;
  • Min, Eung-Gi (Shin-Hwa Pharm. Research Inst.) ;
  • Kim, Yong-Hae (Shin-Hwa Pharm. Research Inst.) ;
  • Han, Yeong-Hwan (Department of Biology, College of Natural Science, Dongguk University)
  • Published : 2001.09.30
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Abstract

The methanolic extract of fruiting body of Paecilomyces tenuipes DGUM 32001 showed significant cytotoxicity against human cancer cells: HepG2 and MCF-7. The methanolic extract was further fractionated with organic solvents such as chloroform and ethyl acetate in that order. Among the fractions tested, the ethyl acetate fraction showed the highest cytotoxicity against the carcinoma tested. The $IC_{50}$ values of ethyl acetate fraction against HepG and MCF-7 were 40 and 9.6 ${\mu}g/ml$, respectively.

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