Deep Vein Thrombosis 진단을 위한 Impedance Plethysmography의 시뮬레이션 연구

A Simulation Study of Impedance Plethysmography for Diagnosing Deep Vein Thrombosis

  • 이전 (연세대 보건과학대 의공학과) ;
  • 이경중 (연세대 보건과학대 의공학과)
  • 발행 : 2001.10.01

초록

In this study, the effects of vascular parameter changes and electrodes on VOP measurement based on IPG were simulated mathematically. For the evaluation of the effects of hemodynamic changes on VOP, a mathematical model, which consists of cardiovascular system model and venous occlusion model, was developed and the model solution representing the blood flow and pressure in measuring point was found by 2nd order Runge-Kutta method. And, with sensitivity coefficients obtained from finite element solution of electric field in measuring point, the effects of electrode system on measurement were evaluated. As increasing the resistance, the venous capacitance was not changed but the venous outflows were decreased and the decreased compliance reduced the venous capacitance. And, for several configurations of round electrodes and band electrodes, the sensitivity coefficients were computed using the electric field distribution along deep vein. In conclusion, the proposed mathematical cardiovascular model could be applied to the simulation study on the effects of hemodynamic parameters on DVT diagnosis with IPG. And, also the sensitivity coefficients could provide effective electrode configuration for exact measurement of VOP.

키워드

참고문헌

  1. S. C. Mullick, H. B. Wheller and G. F. Songster, Diagnosis of deep vein thrombosis by measurement of electrical impedance , Am. J. Surg., vol. 119, pp. 417-422, 1970 https://doi.org/10.1016/0002-9610(70)90143-1
  2. F. A. Anderson Jr., W. W. Durgin and H. Brownell Wheeler, 'Interpolation venous occlusion plethysmography using a non-linear model, Med. Biol. Comput, vol. 24, pp. 379-385, 1986 https://doi.org/10.1007/BF02442692
  3. P. E. Ward, F. B. Bradley, J. G. Brown, W. G. Kernohan, R. C. McGivern and R. A. B. Mollan, 'impedance plethysmo-graphy, Clin. Orthop., vol. 248, pp. 195-199, 1989
  4. A. D. Seagar, J. M. Gibbs and F. M. Davis, 'Interpreta-tion of venous occlusion plethysmographic measurements using simple model, Med. Biol. Eng. Comput, vol. 22, pp. 12-18, 1984 https://doi.org/10.1007/BF02443739
  5. I. C. Turner et al., 'Numerical model of deep venous thrombosis detection using venous occlusion strain gauge plethysmography', Med. Biol. Eng. Comput, Vol. 38, pp. 348-355, 2000 https://doi.org/10.1007/BF02347057
  6. Sverre Grimnes, 'Bioimpedance and Bioelectricity Basics', ACADEMIC PRESS, 2000.
  7. 이전, 박광리, 이경중, '제세동 쇼크에 의한 심장 전류밀도 분포에 관한 시뮬레이션 연구', 대한의용생체공학회, 제21권, 제4호, pp.403-409, 2000
  8. Shen Lou, et al. 'The Electrode System in Impedance-Based Ventilation Measurement', IEEE Transactions on Biomedical Engineering, vol. 39, no. 11, pp. 1130-1141, 1992 https://doi.org/10.1109/10.168692
  9. K. B. Chandran, Cardiovascular biomechanics, New York University Press, 1992.
  10. V. C. Rideout, 'Cardiovascular system simulation in biomedical engineering education', IEEE Trans. Biomed. Eng., Vol. 21, pp. 101-107, March 1972
  11. Ruth Nicholson Klepfer, Christopher R. Johnson, and Robert S. Macleod, 'The Effects of Inhomogeneities and Anisotropies on Electrocardiographic Fields:A 3-D Finite-Element Study', IEEE Transactions on Biomedical Engineering, vol. 44, no. 8, pp. 706-719, 1997 https://doi.org/10.1109/10.605427
  12. A. L. De Jongh, E. G. Entcheva, J. A. Replogle, R. S. Booker, B. H. Kennight, and F. J. Claydon, 'Defibrillation Efficacy of Different Electrode Placements in a Human Thorax Model', PACE, vol. 22, pp. 152-157, 1999 https://doi.org/10.1111/j.1540-8159.1999.tb00323.x
  13. C. R. Johnson, R. S. MacLeod, and P. R. Ershler,' 'A computer model for the study of electrical current flow in the human thorax', Comput. Biol. Med. vol. 22, pp. 305-323, 1992 https://doi.org/10.1016/0010-4825(92)90020-N
  14. N. Khambete, P. Metherall, et al., 'Can We Optimize Electrode Placement for Impedance Pneumography?', Annals of New York Academy of Sciences, vol. 873, pp.534-542, 1999 https://doi.org/10.1111/j.1749-6632.1999.tb09502.x
  15. D. Panescu, J. G. Webster and W. J. Tomkins, 'Optimization of Cardiac Defibrillation by Three-Dimensional Finite Element Modeling of the Human Thorax', IEEE Transactions on Biomedical Engineering, vol. 42, no. 2, pp. 185-191, 1995 https://doi.org/10.1109/10.341831
  16. D. W. Hill and H. J. Lowe, 'The use of the electrical-impedance technique for the monitoring of cardiac output and limb bloodflow during anaesthesia', Medical and Biological Engineering, vol. 11, no. 5, pp. 534-545, September 1973 https://doi.org/10.1007/BF02477397