Journal of the Korean Chemical Society (대한화학회지)

Korean Chemical Society (대한화학회)
권호 표지

Synthesis of New 2-Quinazolylacetonitrile Derivatives

새로운 2-Quinazolylacetonitrile 유도체들의 합성

  • 김정환 (영남대학교 이과대학 화학과) ;
  • 민경수 (영남대학교 이과대학 화학과)
  • Published : 20011200
Download PDF
⟨ Previous Next ⟩

Abstract

2-Quinazolylacetonitrile derivatives containing H-chelate have been synthesized from 2-cyanomethylquinazoline using electrophiles such as 4-chloroquinazoline, 4-chloro-2-phenylquinazoline, 4,6-dichloropyrimidine, 4,6-dichloro-2-phenylpyrimidine, 4,6-dichloro-5-phenylpyrimidine, 2-chloroquinoxaline, 1,3-dichloroisoquinoline, 2,6-dichloropyrazine, 2-chloropyrazine and 4,6-dichloro-2,5-diphenylpyrimidine. These H-chelates may serve as a polymethine chromophore system. Structures of the target molecules were identified by spectral methods.

H-chelate형태의 2-Quinazolylacetonitrile유도체들은 2-cyanomethylquinazoline에 여러가지 친전자체들, 즉, 4-chloroquinazoline, 4-chloro-2-phenylquinazoline, 4,6-dichloropyrinidine, 4,6-dichloro-2-phenylpyrimidine, 4,6-dichloro-5-phenylpyrimidine, 2-chloroauinoxaline,1,3- dichloroisoquinoline, 2,6-dichloropyrazine, 2-chloropyrazine, 4,6-dichloro-2,5-diphenylpyrimidine 등을 반응시켜 얻을 수 있었다. 합성된 H-chelate화합물들은 polymethine계의 발색단 구조를 가지게 된다. 이들 화합물에 대한 구조는 분광학적인 방법으로 분석 확인 하였다.

Keywords

References

  1. J. Org. Chem. v.30 no.243 Borror, A. L.;Haeberer, A. F.
  2. J. Korean Chem. Soc. v.34 no.637 Kim, J. H.;Seo, J. H.
  3. J. Am. Chem. Soc. v.68 no.1300 Endicott, M. M.;Wick, E.;Mercury, M. L.;Sherill, M. L.
  4. J. Korean Chem. Soc. v.45 no.277 Kim, J. H.;Min, K. S.
  5. J. Chem. Soc. v.1927 Schofield, K.
  6. Organic Synthesis Coll. v.2 no.79 Lange, N. A.;Sheibley, F. E.
  7. Synthesis Communications v.239 Sasse, K.
  8. J. Chem. Soc. v.775 Curd, F. H.;Landquist, J. K.;Rose, F. L.
  9. J. Korean Chem. Soc. v.40 no.249 Kim, J. H.;Han, M. S.
  10. J. Korean Chem. Soc. v.44 no.294 Kim, J. H.;Kim, J. O.