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An Efficient and Eco-friendly Approach to $^15N-Unsubstituted {\beta}-Lactams: ^15-Labled$ Synthons for Taxol and Its Analoss


Abstract

An efficient and eco-friendly approach to N-unsubstituted ${\beta}-lactams$ has been developed using mostly water as the reaction medium. This methodology was applied to the synthesis of N-unsubstituted 3-hydroxy-4-phenyl-2-azetidinone derivatives (inclu ding 15N-labeled version) which are suitable precursors for the C-13 side chain of taxol and its analogs.

Keywords

References

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Cited by

  1. Preparation of β-lactams by [2+2] cycloaddition of ketenes and imines vol.64, pp.46, 2008, https://doi.org/10.1016/j.tet.2008.08.028