대한한의학회지 (The Journal of Korean Medicine)

  • 제22권3호
  • /
  • Pages.129-140
  • /
  • 2001
  • /
  • 1010-0695(pISSN)
  • /
  • 2288-3339(eISSN)
대한한의학회 (The Society of Korean Medicine)
권호 표지

분심기음의 우울증 모델 흰쥐에 대한 실험적 연구

The Effects of Punsimgi-eum(fenxinqi-yin) in the Chronic Mild Stress Model of Depression in Rats

  • 이승기 (상지대학교 한방신경정신과) ;
  • 김종우 (경희대학교 한방신경정신과) ;
  • 황의완 (경희대학교 한방신경정신과) ;
  • 김현택 (고려대학교 심리학과) ;
  • 곽소영 (고려대학교 심리학과) ;
  • 박은혜 (고려대학교 심리학과)
  • 발행 : 2001.09.01
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초록

Objectives : The aim of this study was to evaluate the effects of Punsimgi-eum(fenxingi-yin) in rat model of depression induced by chronic mild stress (CMS). Methods : The change of the consumption of sucrose solution was measured, and the open field test and passive avoidance conditioning test were performed to investigate the anti-depressive effect of Punsimgi-eum(fenxingi-yin). Results : The results were as follows; I. The consumption of sucrose solution was significantly reversed in the test group at 5, 7 and 8 weeks, but there was no significant change in the control group. 2. There was no significant change of body weight after 8 weeks in each group 3. In the open field test, there was significant increase of exploratory activity in the test group. 4. In the passive avoidance test, the test group showed differences in the maintenance of retention from the control group at the 2-week training-testing interval. Conclusions : The present results suggest that Punsimgi-eum(fenxingi-yin) has an anti-depressive effect.

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