The Journal of Korean Medicine (대한한의학회지)

The Society of Korean Medicine (대한한의학회)
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Combined Treatment of Colchicine and Herbal Medicines(Gamichunghyulhohyul-tang or Gamiyongdamsagan-tang) Attenuate the Behcet's Disease Symptoms in Mice

베체트병 마우스 모델에서 증상의 호전에 대한 콜키친과 한약(가미청혈보혈탕 또는 가미용담사간탕)의 복합 투여 효과

  • Seong-Hyang, Sohn (Laboratory of Cell Biology, Ajou University Institute for Medical Sciences, Department of Dermatology) ;
  • Dong-Sik, Bang (Yonsei University College of Medicine) ;
  • Seung-Ihm, Lee (Laboratory of Cell Biology, Ajou University Institute for Medical Sciences, Department of Dermatology) ;
  • Hyuk-Jae, Kwon (Laboratory of Cell Biology, Ajou University Institute for Medical Sciences, Department of Dermatology) ;
  • Eun-So, Lee (Ajou University School of Medicine) ;
  • Jang-Hyun, Kim (Dongguk University College of Oriental Medicine) ;
  • Suh-Young, Choi (Hana Medical Foundation) ;
  • Sung-Nack, Lee (Ajou University School of Medicine)
  • Published : 2001.06.01
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Abstract

목적 : 단순포진바이러스로 유발한 베체트병 마우스 모델에서 가미청혈보혈탕과 가미 용담사간탕을 colchicine과 함께 투여할 경우, 한방 혹은 양방 단독 투여의 경우와 비교하여 베체트병 증상의 호전에 어떠한 영향을 주는지 알아보고자 하였다. 방법 : colchicines, 가미 청혈보혈탕, 가미용담사간탕을 각각 또는 colchicines+가미 청혈보혈탕, colchicines+가미용담 사간탕을 20일간 복합 투여하여 베체트 증상이 호전되는 정도를 살펴보고, 호전 되는 증상의 종류를 파악하고, 이때 동반되는 싸이토카인을 RT-PCR, FACS등으로 확인하고자 하였다. 결과 : 단독투여군보다 복합투여군에서 증상이 호전되는 율이 높았으며, 호전 시기를 앞당겼고, 이때 싸이토카인 interteukin-4의 발현이 증가하였다. 결론 ; 베체트병 마우스 모델에서, 양방과 한방의 복합투여가 단독투여보다 증상의 호전에 보다 더 효과적이었다.

Keywords

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