대한한의학회지 (The Journal of Korean Medicine)

  • 제22권1호
  • /
  • Pages.53-62
  • /
  • 2001
  • /
  • 1010-0695(pISSN)
  • /
  • 2288-3339(eISSN)
대한한의학회 (The Society of Korean Medicine)
권호 표지

인진청간탕이 C형 간염 바이러스의 임파구계 세포감염에 미치는 영향

The Effect of Injinchunggan-tang on Hepatitis C Virus Infection

  • 김선민 (경희대학교 한의과대학 간계내과학교실) ;
  • 이장훈 (경희대학교 한의과대학 간계내과학교실) ;
  • 우홍정 (경희대학교 한의과대학 간계내과학교실)
  • 발행 : 2001.03.01
PDF 다운로드
⟨ 이전 논문 다음 논문 ⟩

초록

Objective : The aim of this study was to evaluate the efficacy of Injinchunggan-tang on Hepatitis C virus infection, and to clarify the mechanism of treatment by indentifying the effect of Injinchunggan-tang on cytokine secretion. Methods : In vitro model of HCV infection in MOLT 4 cell was used. The effect of Injinchunggan-tang on the attachment of HCV on MOLT 4 cell was studied by PCR method. The change of cytokine secretion according to Injinchunggan-tang treatment was investigated by ELISA. Results : Injinchunggan-tang inhibited the attachment of HCV on MOLT 4 in the concentration of $10-2{\mu\textrm{g}}/\mu\textrm{\ell}$ and $10-1{\mu\textrm{g}}/\mu\textrm{\ell}$. In cytokine assay, Injinchunggan-tang increased the secretion of IL-4 of mouse splenocytes and PBMC in 48 hour culture as well as the secretion of IL-12 of mouse splenocytes and PBMC in 48 hour culture, whereas it decreased the secretion of $IFN-{\gamma}$ of mouse splenocytes in 24 and 48 hour culture. Conclusion : The results of this study show that Injinchunggan-tang has an inhibitory effect on the attachment on HCV on Mo1t4 Cell, and that it increases the secretion of IL-4 and IL-12 of mouse splenocyte and PBMC.

키워드

참고문헌

  1. 慶熙韓醫大論文集 v.21 no.1 茵陳淸肝湯이 HepG 2.2.15Cell의 HbeAg發顯抑制에 미치는 效果 禹弘楨;李長勳;金善珉
  2. 和漢醫藥學會雜 v.12 C型간염바이러스의 임파구계세포에의 감염에 대한 인삼양영탕의 영향(第1報) 古屋實;丁宗鐵
  3. 和漢醫藥學會雜 v.13 C型간염바이러스의 임파구계세포에의 감염에 대한 인삼양영탕의 영향(第2報) 古屋實;小林嵩雄;飯島廣治;丁宗鐵
  4. 일본동양의학잡지 v.45 한방약에 의한 C型간염바이러스의 임파구계세포에의 흡착억제 古屋實;飯島廣治;丁宗鐵
  5. Current Therapy v.16 no.11 인터페론 治療抵抗性 C型 慢性肝炎의 對策 熊田博光
  6. Current Therapy v.16 no.11 C型肝炎 바이러스와 肝發癌 小原慕子;小原道法
  7. Occup Med v.50 no.6 Hepatitis C virus Stevens, A.B.;Coyle, P.V.
  8. Sex Transm Infect. v.74 Sexual transmission of hepatitis C virus infection Rooney, G.;Gilson, R.J.
  9. Hepatology v.26 no.SUP.1 Management of Hepatitis C National Institutes of Health Consensus Development Conference Panel Statement
  10. 肝系內科學 全國韓醫科大學肝系內科學敎授(共著)
  11. 精校黃帝內經素問 洪元植
  12. 仲景全書 張仲景
  13. 茵陳淸肝湯이 MHV-2로 유발된 마우스의 損傷肝에 미치는 影響 金眞珠
  14. 제2회 韓中學術大會論文集 慢性B型肝炎에 대한 茵陳淸肝湯의 效果 禹弘楨
  15. 茵陳淸肝湯의 安全性에 대한 硏究 金英哲
  16. 茵陳淸肝湯加味方이 實驗的 흰쥐의 肝硬變症에 미치는 影響 姜京太
  17. 茵陳淸肝湯加味方이 肝細胞의 增殖能力에 미치는 影響 박용진
  18. 全國 韓醫學 學術大會 HCV환자에서 茵陳淸肝湯加味方 投與後 Anti-HCV역가의 變化 觀察15例 강우성;金英哲;李長勳;禹弘楨
  19. Analytical Biochemistry v.162 Single-step method of RNA Isolation by Acid Guandidinium Thiocyanate Phenol-Chloroform Extraction Chomczynski, P.;Sacchi, N.
  20. Current Therapy v.16 no.11 C型肝炎 바이러스 백신 開發 松浦善治;石井孝可;鈴木哲郎;宮村達男
  21. Infect Dis Clin North Am. v.14 no.3 Hepatitis C Cheney, C.P.;Chopra, S.;Graham, C.
  22. Vox Sang. v.75 Gollowup to HBV and HCV Carriers in a Blood Center Shimoyama, R.;Kato, T.;Ikada, H.;Sekiguchi, S.
  23. Hepatology v.20 Degree of Diversity of Hepatitis C Virus Quasispecies and Progression of Liver Disease Masao, H.
  24. Bull. Soc. Pathol. Exot. v.91 no.1 Genomic subtypes of hepatitis C virus:epidemiology, diagnosis and clinical consequences Nousbaum, J.B.
  25. 대한 내과학회지 v.49 no.4 C型 만성 간질환 환자에서 혈청 ALT치와 혈청 C型 간염 바이러스 개체수와의 관계 유권
  26. J Hepatology v.27 Significance of IgM anti-HCV core level in chronic hepatitis C Papatheodoridis, G.V.;Delladetsima, J.K.;K atsoulidou, A.;Sypsa, V.;Albrecht, M.;Michel, G.;Hatzakis, A.;Tassopoulos, N.C.
  27. Jo. Clinical Microbiology Preclinical Evaluation of AMPLICOR Hepatitis C Virus Test for Detection of Hepatitis C Virus RNA, Jo Fredericks, S.N.;Cathy, T.;Michael, W.F.
  28. 和漢醫藥學會雜誌 v.11 C型만성간염에 대한 인삼영양탕의 효과 丁宗鐵;小泉久仁;花輪壽顔
  29. 大韓內科學會誌 v.51 Therapeutic Efficacy of Interferon-in Patients with Chronic Hepatitis C-change in Serum HCV-RNA & Anti-HCV 권소영
  30. Consensus Conference on the management of Hepatitis C the need for additional studies on interferon and enw or alternative treatment NIH
  31. Antiviral Research v.42 In vitro effect of amantadine and interferon-2a on hepatitis C virus markers in cultured peripheral blood mononuclear cells from hepatitis C virus-infected patients Julio, M.;Sonia, N.;Mario, F.;Miguel, R.;Margarita, P.;Juan, A.Q.;Friederike, Z.;Vicente, C.
  32. Archives of Virology v.143 Infection of hepatitis C virus adsorption to peripheral blood mononuclear cells by dextran sulfate Cribier, B.;Schmitt, C.;Kirn, A.;Stoll, K.F.
  33. Jo. Medical Virology v.57 Suramin Blocks Hepatitis C Binding to Human Hepatoma Cells In Vitro. Jo Garson, J.A.;Lubach, D.;Passa, J.;Whitby, K.;Grant, P.R.
  34. Transfusion v.30 no.4 Blood screening for non-A, non-B hepatitis by hepatitis C virus antibody assay Kaatayama, T.;Kikuchi, S.;Tanaka, Y.;Saito, I.;Miyamura, T.;Choo, Q.L.;Houghton, M.;Kuo, G.
  35. Hepatology v.23 Hepatitis C Virus:Detection of Intracellular Virus Particles by Electon Microscopy Shimizu, Y.K.;Feinstone, S.M.;Kohara, M.;Purcell, R.H.;Yoshikura, H.
  36. Virology v.208 no.2 Antibodies in human sera specific to hypervariable region 1 of hepatitis C virus can block viral attachment Zibert, A.;Schreier, E.;Roggendorf, M.
  37. Minophagen Medical Review v.41 no.3 劇症性肝炎과 Fas 抗原 梁京賢
  38. Clin Exp Immunol. v.109 Impairment of natural killer cytotoxic activity in hepatitis C virus infection Corado, J.;Toro, F.;Riyera, H.;Bianco, N.E.;Deibis, L.;DeSanctis, J.B.
  39. Jo. General Virology v.79 In vitro infection of adult normal juman hepatocytes in primary culture by hepatitis C virus. Jo Chantal, F.
  40. Int J Immunopharmacol v.22 Modulation of Lung local immune responses by oral administraion of a herbal medicine Sho-saiko-to Ohtake, N.;Suzuki, R.;Daikuhara, H.;Nakai, Y.;Yamamoto, M.;Amagaya, S.;Ishige, A.;Sasaki, H.;Komatsu, Y.;Fukuda, K.;Hayashi, S.
  41. 慶熙大擧校大學院 학위논문 茵陳淸肝湯加味方이 肝細胞의 增殖能力에 미치는 影響 박용진