Toxicological Research
- Volume 17 Issue 2
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- Pages.131-137
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- 2001
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- 1976-8257(pISSN)
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- 2234-2753(eISSN)
Induction of Apoptosis by Baicalein in Human Leukemia HL-60 Cells
- Kim, Jang-Ho (Department of Biology, Kyonggi University) ;
- Park, Sun-Young (Department of Biology, Kyonggi University) ;
- Shin, Kwang-Sig (Department of Biology, Kyonggi University) ;
- Yoo, Byung-Sun (Department of Biology, Kyonggi University)
- Published : 2001.06.01
Abstract
Baicalein, a major flavonoid of extract from Scutellaria baicalensis Georgi, has been shown to exhibit antioxidant and anti proliferative effects. In the present study, we investigate the effects of baicalein on viability and induction of apoptosis in human promyelocytic leukemia HL-60 cells. Baicalein was found to induce apoptosis of HL-60 cells in a concentration-dependent and time-dependent manner. When HL-60 cells were exposed to 100