Toxicological Research
- Volume 17
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- Pages.59-69
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- 2001
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- 1976-8257(pISSN)
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- 2234-2753(eISSN)
Transcription Profiles of Human Cells in Response to Sodium Arsenite Exposure
- Lee, Te-Chang (Institute of Biomedical Sciences, Academia Sinica) ;
- Konan Peck (Institute of Biomedical Sciences, Academia Sinica) ;
- Yih, Ling-Huei (Institute of Biomedical Sciences, Academia Sinica)
- Published : 2001.07.01
Abstract
Arsenic exposure is associated with several human diseases, including cancers, atherosclerosis, hypertension, and cerebrovascular diseases. In cultured cells, arsenite, an inorganic arsenic com-pound, was demonstrated to interfere with many physiological functions, such as enhancement of oxidative stress, delay of cell cycle progression, and induction of structural and numerical changes of chromosomes. The objective of this study is to investigate the effects of arsenic exposure on gene expression profiles by colorimetric cDNA microarray technique. HFW (normal human diploid skin fibroblasts), CL3 (human lung adenocarcinoma cell line), and HaCaT (immortalized human keratinocyte cell line) were treated with 5