대한의생명과학회지 (Biomedical Science Letters)
- 제7권4호
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- Pages.205-210
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- 2001
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- 1738-3226(pISSN)
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- 2288-7415(eISSN)
The Effects of Cyclophosphamide on Apoptosis in Murine Lymphoma
- Yang, Je-Hoon (Department of Organ Physiology, Asan Institute for Life Science) ;
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Bae, Hyung-Joon
(Department of Medical Technology, Seoul Health College) ;
- Seo, Deuk-Rok (Department of Veterinary Histology, Gyeongsang National University) ;
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Koh, Phil-Ok
(Department of Veterinary Histology, Gyeongsang National University) ;
- Kwak, Soo-Dong (Department of Veterinary Histology, Gyeongsang National University)
- 발행 : 2001.12.01
초록
Whereas apoptosis is a critical mode of cell deletion in normal organism development, apoptotic cells are also observed in tumor therapy. We therefore investigated the expression of apoptotic cells induced as a function of time and dose in murine A-20 lymphoma treated with cyclophosphamide in vivo, by H&E and TUNEL method. The percent of apoptotic cells were scored from tumor section using TUNEL method. The expression of apoptotic positive cell was determined over a 10-day period following treatment of the mice with 200 mg/kg. Apoptosis increased further with time, reaching a peak value between 12~24 hr (scored 6.7