한국환경성돌연변이발암원학회지 (Environmental Mutagens and Carcinogens)
- 제21권2호
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- Pages.142-148
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- 2001
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- 1225-6307(pISSN)
Benzidine dihydrochloride에 의한 Chinese hamster lung 세포의 적응반응
Adaptive Response in Chinese Hamster lung Cells by Benzidine Dihydrochloride
초록
We studied adaptive response in CHL cells by benzidine dihydrochloride, a derivative of benzidine, which was a major mutagenic agent in dye industry. Chromosome aberration analysis was used for the identification of adaptive response to this mutagen. Adaptive and reactive doses were confirmed by cell proliferation rate curve. Cell proliferation rate curve was obtained from the mitotic indices of cells treated with various concentrations of benzidine dihydrochloride for 24 hours. Marked adaptive responses to benzidine dihydrochloride in the induction of chromosome aberration were observed in CHL cells by pre-treatment with low concentrations of benzidine dihydrochloride (0.0047 mg/