한국환경성돌연변이발암원학회지 (Environmental Mutagens and Carcinogens)
- 제21권2호
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- Pages.99-105
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- 2001
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- 1225-6307(pISSN)
Genotoxicity Study of Sophoricoside, a Constituent of Sophora japonica, in Bacterial and Mammalian Cell System
- Kim, Youn-Jung (Toxicology Laboratory, Korea Institute of Science & Technology) ;
- Park, Hyo-Joung (Toxicology Laboratory, Korea Institute of Science & Technology) ;
- Kim, Young-Soo (College of Pharmacy, Chungbuk Natl. Univ.) ;
- Kim, Mi-Kyung (College of Medicine, Chungbuk Natl. Univ.) ;
- Lee, Seung-Ho (College of Pharmacy, Yeungnam Univ.) ;
- Jung, Sang-Hun (College of Pharmacy, Chungnam Univ.) ;
- Ryu, Jae-Chun (Toxicology Laboratory, Korea Institute of Science & Technology)
- 발행 : 2001.09.01
초록
Sophoricoside was isolated as the inhibitor of IL-5 bioactivity from Sophora japonica (Leguminosae). It has been reported to has an anti-inflammatory effect on rat paw edema model. To develope as an anti-allergic drug, genotoxicity of sophoricoside was investigated in bacterial and mammalian cell system such as Ames bacterial reversion test, chromosomal aberration assay and single cell gel electrophoresis (Comet) assay. As results, in the range of 1,250~40