Toxicological Research

  • 제17권4호
  • /
  • Pages.287-296
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  • 2001
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  • 1976-8257(pISSN)
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  • 2234-2753(eISSN)
한국독성학회 (Korean Society of Toxicology & Korea Environmental Mutagen Society)
권호 표지

일본 메추리를 이용한 급성 경구독성시험법의 확립

Acute Oral Toxicity Test in Japanese Quail

  • 최은실 (서울대학교 수의과대학 실험동물의학) ;
  • 박종환 (서울대학교 수의과대학 실험동물의학) ;
  • 홍정주 (서울대학교 수의과대학 실험동물의학) ;
  • 박재학 (서울대학교 수의과대학 실험동물의학)
  • 발행 : 2001.12.01
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초록

The acute oral LD5O toxicity values of isazofos, pyraclofos, diazinon and methomyl were determined for Japanese quail based on OECD guideline. The $LD_{50}$ of isazofos, pyraclofos and diazinon was 16.26 mg/kg, and 7.11mg/kg body weight In female respectively. And the $LD_{50}$ of each chemical in male was 21.44, 35.64, 8.28 mg/kg body weight respectively. Diazinon was the most susceptible compounds to Japanese quail in both sexes. The $LD_{50}$ of methomyl was 21.24 mg/kg body weights in female, and 28.28 mg/kg body weight in male respectively. Diazinon, isazofos and methomyl were more toxic In the female than male. The symptoms of poisoning were similar in quails administrated with each chemicals. The clinical sign in Japanese quail were ataxia, salivation, diarrhea, ruffled feather and convulsion at dead point. There were severe hemorrhage and catarrhal inflammation from duodenum to ileum In all compounds. In Japanese quail treated with organophosphorus and carbamate compounds, brain acetylcholinesterase was inhibited by 88-96. The recovery was not observed after 5 h in sublethal dose.

키워드

참고문헌

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