Toxicological Research

Korean Society of Toxicology & Korea Environmental Mutagen Society (한국독성학회)
권호 표지

Reproductive Toxicity Assessment on 2-Bromopropane using Spematogenesis Stage Classification and Sertoli Cell Indices

Spermatogenesis stage 분류와 Sertoli cell indices를 이용한 2-bromopropane의 생식독성평가

  • 정용현 (한국산업안전공단 산업안전보건연구원 산업화학물질연구센터) ;
  • 한정희 (한국산업안전공단 산업안전보건연구원 산업화학물질연구센터) ;
  • 유일재 (한국산업안전공단 산업안전보건연구원 산업화학물질연구센터)
  • Published : 2001.12.01
Download PDF
⟨ Previous Next ⟩

Abstract

This study was carried out to assess the reproductive toxicity of 2-bromopropane (S-BP) using spermatogenesis stage classification and Sertoli cell indices (SCI).Vehicle control olive oil and 2-BP doses of 125, 250 and 500 mg/kg of body weight were injected in the interaperitoneum of 12 weeks male Sprague-Dawley rats for 28 days respectively of SCI on germ cells including the spermatogonia of stages II-III, Ⅵ,Ⅹ, XII, ⅩIII, and spermatocytes of stages VIII (preleptotene), Ⅹ (leptotene), XII (leptotene), V and Ⅵ (pachytene), and the round spermatids of stage Ⅵ. Considering the process of maturation depletion in spermatonesis, spermatogonia may be the primary target cells of 2-BP toxicity.

Keywords

References

  1. Toxicologic Pathology v.25 Evaluation of testicular in safety evaluation studies: the appropriate use of spermatogenic staging Creasy, D.M.
  2. Arch. Toxicol. Suppl. v.7 Aspects of testicular toxicity induced by anticancer drugs Ettlin, R.A.;Bechter, R.;Lee, I.P.;Hodel, C.
  3. Handbook of toxicologic pathology Haschek, W.M.;Rousseaux, C.G.(Eds.)
  4. J. Occup. Health v.39 Testicular and hematopoietic toxicity of 2-bromopropane, a substitute for ozone layer-depletin chlorofluorocarbons Ichihara, G.;Asaeda, N.;Kumazawa, T.;Tagawa, Y.;Kamijima, M.;Yu, X.;Kondo, H.;Nakajima, T.;Kitoh, J.;Yu, I.;Moon, Y.;Hisanaga, N.;Takeuchi, Y.
  5. Scand. J. Work Environ. Health v.22 Hematopoietic and reproductive hazards of Korean electronic works exposed to solvents containing 2-bromopropane Kim, Y.;Jung, K.;Hwang, T.;Jung, G.;Kim, H. :Park, J.;Kim, J.;Park, J.;Park, D.;Park, S.;Choi, K.;Moon, Y.
  6. Vet. Rec. v.103 The Sertoil cell index as a measure of testicular degeneration in the bull Kumi-Diaka, J.;Dennis, S.M.
  7. Draft detailed review paper appraisal of test methods for sex-hormone disrupting chemicals
  8. soft science publications Atlas of testicular seminiferous tubules Takahashi, M.
  9. Scand. J. Work Environ. Health v.23 Reproductive toxicity of 2-bromopropane in Sprague Dawley rats Yu, I.J.;Chung, Y.H.;Lim, C.H.;Maeng, S.H.;Lee, J.Y.;Kim, H.Y.;Lee, S.J.;Kim, C.H.;Kim, T.G.;Lim, C.H.;Park, J.S.;Moon, Y.H.