Animal cells and systems

The Korean Society for Integrative Biology (한국통합생물학회)
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Involvement of Nek2 in Mammalian Development as a Cell Cycle Regulator

  • Kim, Yong-Ha (School of Biological Sciences, Seoul National University) ;
  • Rhee, Kunsoo (School of Biological Sciences, Seoul National University)
  • Published : 2001.09.01
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Abstract

Nek2 is a mammalian protein kinase that is structurally homologous to NIMA, a mitotic regulator in Aspergillus nidulans. To understand cellular processes in which Nek2 participates during mammalian development, we investigated the expression and subcellular localization of Nek2 in vivo. The Nek2 protein was detected in spermatocytes and in a fraction of actively dividing ovarian follicle cells and of embryonic tissues. We also observed that Nek2 was localized in both the nucleus and centrosome in embryonic cells. Such localization pattern supports the proposal that Nek2 is a mitotic regulator that is involved in multiple cell cycle events during mammalian development.

Keywords

References

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