YAKHAK HOEJI (약학회지)

The Pharmaceutical Society of Korea (대한약학회)
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Identification of Bak-like Protein cDNA

Bak-like 단백질을 code하는 cDNA의 동정

  • 김진경 (포천중문의과대학교, 여성의학연구소)
  • Published : 2001.08.01
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Abstract

Cells are eliminated in a variety of physiological settings by apoptosis, a genetically encoded process of cellular suicide. Bak, a member of the Bcl-2 protein family, accelerates apoptosis by an unknown mechanism. We have found a novel cDNA encoding a 101 amino acid protein possessing a Bak-like in our full-length cDNA bank. Bak-like shares the conserved domains BHI and 2 with other proapoptotic proteins but lacks the BH3 domain. Bak-like is expressed in a wide variety of tissues. Like Bak, Bak-like gene product primarily enhances apoptotic cell death following an appropriate stimulus.

Keywords

References

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