YAKHAK HOEJI (약학회지)

The Pharmaceutical Society of Korea (대한약학회)
권호 표지

Synthesis and Antimicrobial Activity of 10-Substituted Levofloxacin Derivatives

10-(치환)-레보푸록사신 유도체의 합성 및 항균 작용

  • Published : 2001.08.01
Download PDF
⟨ Previous Next ⟩

Abstract

A series of (-)-9-fluoro-2,3-dihydro-3(S)-methyl-10-(4-substituted-1-piperazinyl)-7-oxo-7H-pyrido [1,2,3-de] [1,4]-benzoxazine-6-carboxylic acid (5-8) was synthesized and evaluated for antibacterial activity against gram(+) and gram(-) bacteria. These synthesized compounds showed a lower activity than levofloxacin.

Keywords

References

  1. J.Med.Chem. v.23 Structure-activity relationship of anti-bacterial 6,7-and 7,8-disubstituted1-alky1-[1,4]-dihydro-4-oxoquinoline-3-carboxylic acid Koga,H;Itoh,A;Murayama,S;Suzue,S;Irikura,T
  2. J.Med.Chem. v.27 Synthesis an structure-activity relationships of 1,6,7-trisubstituted [1,4]-dihydro-4-oxo1,8-naphtlyridine-3-carboxylic acids,including enoxacin,a new antibacterial agent Matsumoto,J;Miyamoto,T;Minamida,A;Nishimura,Y
  3. Drugs v.35 Ciprofloxacin.A review of its antibacterial activity,pharmacokinetic properties and therapeutic use Campoli,D.M;Monk,J.P;Price,A;Benfield,P;Todd,P.A;Ward,A
  4. J.Med.Chem v.27 Novel amino-substituted 3-quinoline carboxylic acid antibacterial agents:Synthesis and structure activity relationships Wentland,M.P;Bailey,D.M;Cornett,J.P
  5. Drugs v.37 Perfloxacin.A review of its antibacterial activities,pharmacokinetic properties and therapeutic use Gonzalez,J.P;Henwood,J.M
  6. Abstracts 25th interscience conference on antimicrobial agents and chemotherapy Gerster,J.F;Rohlfing,S.R;Pecore,S.E;Winandy,R.M;Stern,R.M;Landmesser,J.E;Olsen,R.A;Gleasen,W.B
  7. Chem.Pharm.Bull. v.34 no.10 A new synthesis of 7H-pyrido [1,2,3-de][1,4]benzoxazine derivatives including and antibacterial agent,Ofloxacin Egawa,H;Miyamoto,T;Matsumoto,J-I
  8. J.Med.Chem. v.30 Chiral DNA gyrase inhibitors 2:Asymmetric synthesis and biological activity of the enantiomers 9-fluoro-3-methy-10-(4-methy]-1-piperaziny1)-7-oxo-2,3-dihydro-7H-pyrido [1,2,3-de]-1,-benzoxazine-6-carboxylic acid (Ofloxacine) Mitscher,L.A;Sharma,P.N;Chu,D.T.W;Shen,L.L;Pernet,A.G
  9. Chem.Pharm.Bull. v.32 no.12 Syntiesis and antibacterial activities of substituted 7-Oxo-2,3-dihydro-7H-pyrido[1,2,3-de] [1,4] benzoxazine-6-carboxylic acids Hayakawa,I;Hiramitsu,T;Tanaka,Y
  10. Chem.Pharm.bull. v.35 no.5 Synthesis and antibaterial activities of optically active Ofloxacin and its fluoromethyl derivatives Atarashi,S;Yokohama,S;Yamazaki,K.I;Sakano,K.I;Imamura,M;Hayakawa,I