YAKHAK HOEJI (약학회지)

The Pharmaceutical Society of Korea (대한약학회)
권호 표지

Sesquiterpene Lactones of Artemisia sylvatica

그늘쑥의 Sesquiterpene Lactone 성분

  • 권학철 (성균관대학교 약학대학 천연물약품화학연구실) ;
  • 최상진 (성균관대학교 약학대학 천연물약품화학연구실) ;
  • 이원빈 (성균관대학교 약학대학 천연물약품화학연구실) ;
  • 민용득 (성균관대학교 약학대학 천연물약품화학연구실) ;
  • 양민철 (성균관대학교 약학대학 천연물약품화학연구실)
  • Published : 2001.04.01
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Abstract

The phytochemical study of the aerial parts of Artemisia sylvatica (Asteraceae) led to the isolation of nine sesquiterpene lactones, l$\alpha$-hydroperoxy-rupicolin A acetate (1), rupicolin B acetate (2), rupicolin A acetate (3), l$\alpha$-hydroxy-4$\alpha$-hydroperoxy-bishopsolicepolide (4), 1$\alpha$-hydroperoxy-4$\beta$-hydroxy-8$\alpha$-acetoxy-guaia-2,9,11 (13)-triene-6$\alpha$,12-oxide (5), 1$\alpha$-hydroperoxy-4$\alpha$-hydroxybishopsolicepolide (6), l$\alpha$,4$\beta$-dihydroxy-8$\alpha$-acetoxy-guaia-2,9,11(13)-triene-6$\alpha$,12-olive (7), rupicolin A (8) and l$\alpha$,4$\alpha$-dihydroxy-bishopsolicepolide (9). Their structures were established by chemical and spectroscopic methods.

Keywords

References

  1. Studies in Natural Products Chemistry;Natural Products from the Genus Artemisia L. v.7 Marco, J.A.;Barbera, O.;Atta-ur-Rahman(ed.)
  2. Phytochemistry v.18 Sesquiterpene lactones and systematics of the genus Artemisia. Kelsey, R.G.;Shafizadeh, F.
  3. Planta Med. v.64 Biologically active substances from the genus Artemisia Tan, R.X.;Zheng, W.F.;Tang, H.Q.
  4. Life Sciences v.66 Current status of artemisinin and its deribatives as antimalarial drugs Dhingra, V.;Rao, K.V.;Narasu, M.L.
  5. Sungkyun Pharm. J. v.4 Sesquiterpene Lactone Lee, K.R.
  6. Tetrahedron v.56 Sesquiterpene lactones, inhibitors of farnesyl protein transferase, isolated from the flower of Artermisia sylvatica Lee, S.H.;Kang, H.M.;Song, H.C.;Lee, H.S.;Lee, U.C.;Son, K.H.;Kim, S.H.;Kwon, B.M.
  7. J. Org. Chem. v.63 Arteminolide, an inhibitor of farnesyl transferase from Artermisia sylvatica Lee, S.H.;KIm, M.J.;Bok, S.H.;Lee, H.S.;Kwon, B.M.
  8. Kor. J. Pharmacogn. v.30 Phytochemical constituents of Artemisia sylvatica Max. Moon, H.I.;Kwon, H.C.;Zee, O.P.;Lee, K.R.
  9. Kor. J. Pharmacogn. v.22 Peroxide comstituents in the natural product research Lee, K.R.
  10. Phytochemistry v.19 Neue Guaianolide aus Cacosmia rugosa Bohlmann, F.;Knoll, K.H.;Robinson, H.;King, R.M.
  11. Phytochemistry v.25 Eudesman-12,8β-olides and other terpenes from Artemisia species Greger, H.;Zdero, C.;Bohlmann, F.
  12. Phytochemistry v.24 Highly oxygenated guaianolides from Bishopanthus soliceps Singh, P.;Jakupovic, J.;Bohlmann, F.;KIng, R.M.;Robinson, H.
  13. Phytochemistry v.27 Glaucolides and guaianolides from Artemisia afra Jakupovic, J.;Klemeyer, H.;Bohlmann, F.;Graven, E.H.
  14. Planta Med. v.57 Sesquiterpene lactones of Achillea setacea with antiphlogistic activity Zitterl-Eglseer, K.;Jurenitsch, J.;Korhammer, S.;Haslinger, E.;Sosa, S.;Della, L.R.;Kubelka, W.;Franz, C.