YAKHAK HOEJI (약학회지)

The Pharmaceutical Society of Korea (대한약학회)
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2-(1-Aminoacetyloxyalkyl)-1,4-Dihydroxy-9,10-Anthraquinone Derivatives: Synthesis and Cytotoxic Activity

2-(1-아미노아세칠옥시알킬)-1,4-디하이드록시-9,10-안트라퀴논 유도체의 합성 및 세포독성 평가

  • Published : 2001.04.01
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Abstract

To improve water solubility of 1,4-dihydroxy-9,10-anthraquinone moiety, 23 of 2-(1-aminoacetylalkyl)-1,4-dihydroxy-9,10-anthraquinone derivatives, which contain nitrogen atom, were synthesized. Of the synthesized compounds, 18 compounds were more cytotoxic on L1210 cells than 2-(1-acetyloxyalkyl)-1,4-dihydroxy-9,10-anthraquinone as comparative structure. This result might be due to the increased hydrophilicity of the compounds.

Keywords

References

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