YAKHAK HOEJI (약학회지)

The Pharmaceutical Society of Korea (대한약학회)
권호 표지

Protective Effects of Green Tea Catechins and (-)-Epigallocatechin gallate on Reactive Oxygen Species-Induced Oxidative Stress

녹차카테킨과 에피갈로카테킨갈레이트의 산화적 스트레스에 대한 억제효과

  • Published : 2001.02.01
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Abstract

Green tea catechins (GTC) and its major component, (-)-epigallocatechin gallate (EGCG) were studied for their protective effects against reactive oxygen species (ROS)-induced oxidative stress. GTC and EGCG skewed the strong antioxidative effects on the lipid peroxidation of ethyl linolate with Fenton's reagent and free radical scavenging effect to DPPH radical generation. They also protected $H_2O$$_2$- or KO$_2$-induced cytotoxicity in CHL cells or mouse splenocytes. These results indicate that GTC and EGCG are capable of protecting the lipid peroxidation, flee radical generation and cytotoxicity induced by ROS. The mechanism of inhibition in ROS-induced cytotoxicity may be due to their antiofidative and free radical scavenging properties. Therefore, GTC and EGCG may be useful chemopreventive agents by protecting the free radical generation which are involved in cancer and aging.

Keywords

References

  1. Nippon Nogeikagaku Kaishi v.61 Angiotensin converting enzyme inhibiting activity of tea components Hara, Y., Matsuzaki, T;Suzuki, T
  2. Nippon Nogeikagaku Kaishi v.59 Antioxidative activity of tea leaf catechins Matsuzaki, T;Hara, Y
  3. Cancer Res v.52 Inhibition of tobacco-specific nitrosamine-induced lung tumorigensis in A/J mice by green tea and its major polyphenol as antioxidants Xu, Y., Ho, C. T., Amin, S. C., Han, C;Chung, F. L
  4. Prev. Med v.21 Suppression of Genotoxicity of carcinogens by (-)epigallocatechin gallate Hayatsu, H., Inada, N., Kakutani, T., Arimoto, S., Negishi, T., Mori, K., Okuta, T;Sakata, I
  5. J. Leukoc. Biol v.51 Stimulation of human monocyte and polymorphonuclear cell iodination and interleukin-1 production by epigallocatechin gallate Sakagami, H., Asano, K., Hara, Y;Shimamura, T
  6. Caries Res v.25 Anticaries effects of polyphenolic compoumds from Japanese green tea Otake, S., Makimura, M., Kuroki, T., Nishihara, Y;Hirasawa, M
  7. Chem. Pharm. Bull v.38 Platelet aggregation inhibitors in hot water extract of green tea Sagesaka-Mitane, Y., Miwa, M;Okada, S
  8. Nippon Nogeikagaku Kaishi v.63 A simple preparative chromatographic separation of green tea catechins Yayabe, F., Kinugasa, H;Takeo, T
  9. J. Fd. Hyg. Safety v.11 no.2 The antithrombotic effects of green tea catechins Yun, Y. P., Kang, W. S;Lee, M. Y
  10. J. Fd. Hyg. Safety v.11 no.2 The effects of green tea catechins on vascular smooth muscle tension and Ca2+ uptake Ahn, H. Y., Lee, M. Y;Yun, Y. P
  11. Thromb. Rese v.96 kAntithrombotic activities of green tea catechins and (-) epigallocatechin gallate Kang, W. S., Park, J. B;Yun, Y. P
  12. Mol. Biol. Cell v.10 no.4 Epigallocatechin-3-gallate, selectively inhibits the PDGF-BB-induced intracellular signaling transduction pathway in vascular smooth muscle cells and inhibits transformation of sis-transfected NIH 3T3 fibroblasts and human glioblastoma cells(A172) Ahn, H. Y., Hadizadeh, K. R., Seul, S., Yun, Y. P;Sachinidis, A
  13. J. Agric. Food Chem v.40 Antioxidative activity of an isoflavonoid, 2-o-glycosylisovitexin isolated from green barlet leaves Kitta, K., Hagiwara, Y;Shibamoto, T
  14. Anal. Biochem v.95 Assay for lipid peroxides in animal tissues by thiobarbituric acid reaction Ohtka, H., Ohishi, N;Yaki, K
  15. Yakugaku Zasshi v.108 Studies on inhibition mechanism of auto-oxidation by tannins and flavonoids Fugita, Y., Uera, L., Morimoto, Y., Nakajima, M., Hatano, C;Okuda, T
  16. Cancer Chemother. Pharmacol v.17 Rapid chemosensitivity testing of human lung tumor cells using the MTT assay Cole, S. P. C
  17. Life Sci v.61 Inhibitory effects of jasmine green tea epicatechin isomers on free radical-induced lysis of red blood cells Zhang, A., Zhu, Q. Y., Luk, Y. S., Fung, K. P;Chem, Z. Y
  18. Prev. Med v.21 no.4 Antioxidative effect of polyphenol extract prepared from various Chinese teas Ho C. T., Chen, Q., Shi, H., Zhang, K. Q;Rosen, R. T
  19. J. Cell Biochem. Suppl v.27 Tea antioxidants in cancer chemoprevention Katiyar, S. K;Mukhtar, H
  20. Biochem. Mol. Biol. Int v.42 no.1 Hydroxyl and superoxide anion radical scavenging activities of natural source antioxidants using the computerized JES-FR30 ESR spectrometer system Noda, Y., Anzai, K., Mori, A., Kohno, M., Shimme, M;Packer, L
  21. Biochem. Biophys. Acta v.1304 Studies on protective mechanisma of four components of green tea polyphenols against lipid peroxidation in synaptosomes Guo, Q., Zhao, B., Li, M., Shen, S;Xin, W
  22. Biol. Pharm. Bull v.19 Effect of plant phenolics on the formation of the spin-adduct of hydroxyl radical and the DNA strand breaking by hydroxyl radical Hiramoto, K., Ojima, N., Sako, K;Kikugawa, K
  23. Jap. J. Cancer Res v.86 Inhibition of 1,2-dimethylhydrazine-induced oxidative DNA damage by green tea extract in rat Inagake, M., Yamane, T., Kitao, Y., Oya, K., Matsumoto, H., Kikuoka, N., Nakatani, H., Takahashi, T., Nishimura, H;Iwashima, A
  24. Phys. Rev v.59 Hydroperoxide metabolism in mammalian organs Chance, B. Siers, H;Boveris, A
  25. Mutation Res v.214 Endogeneous DNA damage as related to cancer and aging Ames, B. N
  26. Science v.221 Dietary carcinogens and anticarcinogens. Oxygen radical and degenerative diseases Ames, B. N
  27. Mutation Res v.267 Assessment of antimutagenicity and anticarcinogenicity Flora, S., Bronzetii, G;Sovels, F. H