Environmental Analysis Health and Toxicology

The Korean Society of Environmental Health and Toxicology (환경독성보건학회)
권호 표지

Study on Inhalation Toxicity of 1-Hexene in SD Rats

SD Rats를 이용 1-hexene의 흡입독성 연구

  • 김현영 (한국산업안전공단 산업안전보건연구원 산업화학물질연구센터) ;
  • 임철홍 (한국산업안전공단 산업안전보건연구원 산업화학물질연구센터) ;
  • 정용현 (한국산업안전공단 산업안전보건연구원 산업화학물질연구센터) ;
  • 이권섭 (한국산업안전공단 산업안전보건연구원 산업화학물질연구센터) ;
  • 이성배 (한국산업안전공단 산업안전보건연구원 산업화학물질연구센터) ;
  • 이준연 (한국산업안전공단 산업안전보건연구원 산업화학물질연구센터) ;
  • 한정희 (한국산업안전공단 산업안전보건연구원 산업화학물질연구센터) ;
  • 전윤석 (한국산업안전공단 산업안전보건연구원 산업화학물질연구센터) ;
  • 이용묵 (한국산업안전공단 산업안전보건연구원 산업화학물질연구센터)
  • Published : 2001.12.01
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Abstract

The purpose of this study was to investigate the acute (4 hours) and repeated-dose (6 hours a day, 5 days a week, 4 weeks) toxic effects of 1-hexene on Sprague-Dawley (SD) rats which were treated by inhalation. The results were as follows; 1. The median lethal concentration(LC$_{50}$) was estimated 52,694 ppm (confidence limit 95％; 49,494~55,447 ppm) in acute inhalation. Abnormal clinical signs related to the 1-Hexene were not observed with the acute inhalation dose. Cross findings of necropsy revealed on evidence of specific toxicity related to the 1-hexene. II. By repeated inhalation exposure the body weight of male were more or less reduced by the dose of 2,500 ppm and 5,000 ppm compared with control group. However there were no significant variation hematology and blood biochemistry for the exposed rats compared with the control rats. Abnormal clinical signs and gross findings of necropsy related to the 1-hexene were not shown. In conclusion when we exposed 1-hexene to SD rats for 4 weeks, 5 days per week, 6 hours per day, the Lowest observed effect level (LOEL) was over 2,500 ppm and Non observed effect level (NOEL) was below 500 ppm.

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