Archives of Pharmacal Research

  • 제24권6호
  • /
  • Pages.499-502
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  • 2001
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  • 0253-6269(pISSN)
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  • 1976-3786(eISSN)
대한약학회 (The Pharmaceutical Society of Korea)
권호 표지

Evaluation of the Role of Imidazolidinone Motif of Antineoplastic 4-Phenyl-1-arylsulfonylimidazolidinones Using 4-Phenyl-2-arylsulfonyloxazolines

  • 발행 : 2001.12.01
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초록

To evaluate the role of imidazolidinone moiety of potential anticancer 4-phenyl-1-arylsulfonylimidazolidinones 1 for their cytotoxicity conformationally similar 4-phenyl-2-arylsulfonylaminooxazolines 2 were synthesized and compared their cytotoxicities with those of the corresponding 1. Compounds 2 showed much reduced activity compared to N-arylsulfonylimidazolidinones 1. This result might indicate that the imidazolidinone ring of 1 have the other roles for the activity as an essential structural motif in addition to conformational contribution .

키워드

참고문헌

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