Archives of Pharmacal Research

The Pharmaceutical Society of Korea (대한약학회)
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Evaluation of the Role of Imidazolidinone Motif of Antineoplastic 4-Phenyl-1-arylsulfonylimidazolidinones Using 4-Phenyl-2-arylsulfonyloxazolines

  • Published : 2001.12.01
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Abstract

To evaluate the role of imidazolidinone moiety of potential anticancer 4-phenyl-1-arylsulfonylimidazolidinones 1 for their cytotoxicity conformationally similar 4-phenyl-2-arylsulfonylaminooxazolines 2 were synthesized and compared their cytotoxicities with those of the corresponding 1. Compounds 2 showed much reduced activity compared to N-arylsulfonylimidazolidinones 1. This result might indicate that the imidazolidinone ring of 1 have the other roles for the activity as an essential structural motif in addition to conformational contribution .

Keywords

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