Archives of Pharmacal Research

The Pharmaceutical Society of Korea (대한약학회)
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Nob1e2-[3-(Cyclopentyloxy)-4-Methoxyphenyl]-1-Isoindolinone Derivatives. PartI: Synthesis and SAR Studies for the Inhibition of TNF-$\alpha$ Production

  • Park, Joon-Seok (Institute of Bioscience ＆ Biotechnology, Daewoong Pharm Co.,) ;
  • Baik, Kyong-Up (Institute of Bioscience ＆ Biotechnology, Daewoong Pharm Co.,) ;
  • Cho, Jae-Youl (Institute of Bioscience ＆ Biotechnology, Daewoong Pharm Co.,) ;
  • Yoo, Eun-Sook (Institute of Bioscience ＆ Biotechnology, Daewoong Pharm Co.,) ;
  • Byun, Young-Seok (Institute of Bioscience ＆ Biotechnology, Daewoong Pharm Co.,) ;
  • Park, Myung-Hwan (Institute of Bioscience ＆ Biotechnology, Daewoong Pharm Co.,)
  • Published : 2001.10.01
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Abstract

This study describes the synthesis and in vitro evaluation of noble 2-[3-(cyclopentyloxy)-4-methoxyphenyl]-1-isoindolinone Derivatives for the inhibition of TNF-$\alpa$ production. Among these compounds, 2- [3- (Cyclopentyloxy)- 4- methoxyphenyll- 3- methyl -1 - isoindolinone (5) was the most potent in inhibitory activity of TNF-$\alpa$ production in LPS-stimulated RAW264.7 cells.

Keywords

References

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