Archives of Pharmacal Research

The Pharmaceutical Society of Korea (대한약학회)
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Prolyl Endopeptidase Inhibitors from Green Tea

  • Kim, Jin-Hui (Dept. of Agricultural Chemistry, College of Agriculture, Kyungpook National University) ;
  • Kim, Sang-In (Dept. of Agricultural Chemistry, College of Agriculture, Kyungpook National University) ;
  • Song, Kyung-Sik (Dept. of Agricultural Chemistry, College of Agriculture, Kyungpook National University)
  • Published : 2001.08.01
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Abstract

Three prolyl endopeptidase (PEP) inhibitors were isolated from the methanolic extract of green tea leaves. They were identified as (-)-epigallocatechin gallate, (-)-epicatechin gallate, and (+)-gallucatechin gallate with the $IC_{50}$ values of 1.42${\times}$$10^{-4}$mM, $1.02{\times}10^{-2}$mM, and $1.09{\times}10^{-4}$mM, respectively. They were non-competitive with a substrate in Dixon plots and did not show any significant effects against other serine proteases such as elastase, trypsin, and chymotrypsin, suggesting that they were relatively specific inhibitors against PER The isolated compounds are expected to be useful for preventing and curing of Alzheimer's disease.

Keywords

References

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