Archives of Pharmacal Research

The Pharmaceutical Society of Korea (대한약학회)
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Chiral Separation of ${\beta}_2$-Agonists by Capillary Electrophoresis Using Hydroxypropyl-${\alpha}$-Cyclodextrin as a Chiral Selector

  • Published : 2001.08.01
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Abstract

Enantiomers of five racemic ${\beta}_2$-agonists were investigated by capillary electrophoresis employing a hydroxypropyl-${\beta}$-cyclodextrin (HP-${\beta}$-CD). The effects of the concentration of HP-${\beta}$-CD added to the background electrolyte and of the pH of the buffer on the effective mobility and resolution of the studied compounds were examined. Very good resolution was achieved for terbutaline and clenbuterol; salbutamol and bambuterol was able to be partially resolved. Enantioselectivity and resolution were influenced by the concentration of the HP-7-CD, buffer composition and pH.

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References

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