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The Pharmaceutical Society of Korea (대한약학회)
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Structure-Activity Relationship Studies of Isoquinolinone Type Anticancer Agent

  • Cheon, Seung-Hoon (College of Pharmacy, Chonnam National University, and Research Institute of Drug Development, Chonnnam National University) ;
  • Park, Joon-Suck (College of Pharmacy, Chonnam National University, and Research Institute of Drug Development, Chonnnam National University) ;
  • Lee, Joon-Yeol (College of Pharmacy, Chonnam National University, and Research Institute of Drug Development, Chonnnam National University) ;
  • Lee, You-Na (College of Pharmacy, Chonnam National University, and Research Institute of Drug Development, Chonnnam National University) ;
  • Yi, Hyo (College of Pharmacy, Chonnam National University, and Research Institute of Drug Development, Chonnnam National University) ;
  • Lee, Chong-Ock (Screening ＆Toxicology Research Center, Korea Research Institute of Chemical Technology)
  • Published : 2001.08.01
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Abstract

Substituted isoquinolin-1-ones (1) were synthesized to test their in vitro anticancer activity. 3-Biphenyl-H-methylisoquinolin-1-one (7) showed the most potent anticancer activity against five different human cancer cell lines.

Keywords

References

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