Archives of Pharmacal Research

  • 제24권3호
  • /
  • Pages.211-213
  • /
  • 2001
  • /
  • 0253-6269(pISSN)
  • /
  • 1976-3786(eISSN)
대한약학회 (The Pharmaceutical Society of Korea)
권호 표지

Cytotoxic Constituents of Psoralea corylifolia

  • Mar, Woong-chon (Natural Products Research Institute, Seoul National University) ;
  • Je, Kang-Hun (Natural Products Research Institute, Seoul National University) ;
  • Seo, Eun-Kyoung (Natural Products Chemistry Laboratory, Collgeg of Pharmacy, Ewha University)
  • 발행 : 2001.06.01
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초록

A coumestan derivative, psoralidin (1) was found to be a cytotoxic principle of the seeds of Psoralea corylifolia L (Leguminosae) with the IC_{50}$ values of 0.3 and 0.4 ug/ml against the HT-29 (colon) and MCF-7 (breast) human cancer cell lines, respectively. A coumarin, angelicin (2) was also isolated as a marginally cytotoxic agent along with an inactive compound, psoralene (3) from the plant. The isolates 1-3 were not active against the A54l(lung) and HepG2 (liver hepatoma) cancer cell lines.

키워드

참고문헌

  1. Phytochemistry v.6 Psoralen, an inhibitor in the seeds of Psoralea subacaulis Baskin,J.M.;Ludlow,C.J.;Harris,T.M.;Wolf,F.T.
  2. Chinese herbal medicine: Materia Medica(Revised edition) Bensky,D.;Gamble,A.
  3. Int. J. Pharmacog. v.29 Furocoumarin contents in the vegetative organs of cultivated Psoralea species Inocenti,G.;Cappelletti,E.M.;Caporale,G.
  4. Heterocyles v.31 Bakuchicin, a new simple furanocoumarin from Psoralea corylifolia Kondo,Y.;Kato,A.;Kubota,Y.;Nozoe,S.
  5. Tetrahedron v.29 Monoterpenoids. 1. Psoralea corylifolia Linn. 1. bakuchiol, a novel monoterpene phenol Mehta,G.;Naysak,U.R.;Dev,S.
  6. Planta Med. v.62 Effect of crude fractions of Psoralea corylifolia seed extract on bone calcification Miura,H.;Nishida,H.;linuma,M.
  7. Arch. Pharm. Res. v.15 Antitumor activity of Psoralea corylifolia Ryu,S.Y.;Choi,S.U.;Lee,C.C.;Zee,O.P.
  8. J. Nat. Prod. v.59 Antiplatelet flavonoids from seeds of Psoralea corylifolia Tsai,W.J.;Hsin,W.C.;Chen,C.C.
  9. Planta Med. v.62 The cytotoxicity of Psoralidin from Psoralea corylifolia Yang,Y.M.;Hyun,J.W.;Sung,M.S.;Chung,H.S.;Kim,B.K.;Paik,W.H.;Kang,S.S.;Park,J.G.