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The Pharmaceutical Society of Korea (대한약학회)
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Inhibition of Calmodulin-Dependent Calcium-ATPase and Phosphodiesterase by Various Cyclopeptides and Peptide Alkaloids from the Zizyphus Species

  • Hwang, Keum-Hee (Institute of Health Nutrition, Konkuk University) ;
  • Han, Yong-Nam (Natural Products Research Institute, Seoul National University) ;
  • Han, Byung-Hoon (Natural Products Research Institute, Seoul National University)
  • Published : 2001.06.01
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Abstract

The effects of various sedative cyclopeptides and peptide alkaloids from the Zizyphus species on calmodulin-dependent $Ca^{2+}$ -ATPase and phosphodiesterase were Investigated. Calmodulin-induced activation of $Ca^{2+}$-ATPase was strongly inhibited by sanjoinine-A dialdehyde (IC_{50}$, 2.3$\mu\textrm{m}$), -Ah1 (IC_{50}$, 4.0$\mu\textrm{m}$), -A (IC, 4.6$\mu\textrm{m}$), and -G2 (IC_{50}$, 7.2$\mu\textrm{m}$), while calmodulin-induced activation of phosphodiesterase was strongly inhibited by both deachuine- S10 (IC_{50}$, 4.9$\mu\textrm{m}$) and sanjoinine-D (IC_{50}$, 9.0$\mu\textrm{m}$). The inhibitory activity of the various cyclopeptides and peptide alkaloids on $Ca^{2+}$-ATPase was found to correlate well with their Sedative activity.

Keywords

References

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