Synthesis and in Vitro Antibacterial Activity of Cephalosporins with a Pyridiniume Substituent Carrying an Isoxazole Moiety at the C-3 Position

Several quaternary pyridinium cephalosporin analogues were prepared analogues were Prepared and evaluated in vitro for antibacterial activity against selected Gram-positive and Cram-negative organisms. Most of the synthesized analogues were either as effective or less effective against the tested bacterial organ isms than the reference com pounds, Cefpirome and Ceftazidime.