Archives of Pharmacal Research
- Volume 24 Issue 1
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- Pages.39-43
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- 2001
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- 0253-6269(pISSN)
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- 1976-3786(eISSN)
Photocleavage of DNA by 4'-Bromoacetophenone Analogs
- Jeon, Ra-Ok (College of Pharmacy, Sookmyung Women′s University) ;
- Pual A.Wender (Department of Chemistry, Stanford University)
- Published : 2001.02.01
Abstract
4'-Bromoacetophenone analogs, which are able to generate monophenyl radicals capable of hydrogen atom abstraction, were investigated as possible photoinducible DNA cleaving agents. The potential of 4'-Bromoacetophenone as a possible new DNA cleaver is explored. Pyrrolecarboxatmid conjugated 4'-Bromoacetophenone, in particular, DNA cleaving activity and sequence-selectivity on the contiguous AT base pair sites.