YAKHAK HOEJI (약학회지)

The Pharmaceutical Society of Korea (대한약학회)
권호 표지

carbofuran Induces Cardiovascular Dysfunction in Rat

휜쥐의 심혈관 기능에 대한 carbofuran독성작용

  • Published : 2001.12.01
Download PDF
⟨ Previous Next ⟩

Abstract

Of all pesticides, carbamates are known to be most common, since alternatives such as organophosphates have long lifetime and are extremely toxic to produce a delayed neurotoxic effect. Although a number of studies about toxicity of carbofuran, a most widely used carbamate, have been reported, its cardiovascular toxicity has not yet been studied. In the present study, we investigated its cardiovascular toxic effect in anesthetized rat in vivo and in isolated Langendorff rat heart, In anesthetized rat model, carbofuran (10 mg/kg) significantly reduced heart rate, and transiently increased blood pressure. In isolated rat heart, carbofuran (10${\mu}{\textrm}{m}$) caused a significant depression in the left ventricular developed pressure (LVDP), indicating contractile dysfunction by carbofuran. Carbofuran (10${\mu}{\textrm}{m}$) also decreased coronary flow rate (CFR) in isolated heart, indicating carbofuran-induced coronary dysfunction. These results suggest that carbofuran can cause cardiac dysfunction in rat in vivo and vitro.

Keywords

References

  1. J. Toxicol. Environ. Health v.54 no.1 Efects of the pesticides carbofuralin, chlorpyrifos, dimethoate, lindane, triallate, trifluraline and reproductive endocrine system in ewes Rawlings, N.C.;Cook, S.J.;Waldbillig, D.
  2. Hum. Exp. Toxical v.14 no.11 Effect of oral administration of carbofuran on male reproductive system of rat Pant, N.;Prasad, A.K.;Srivastava, S.C.;Shankar, R.;Srivastava, S.P.
  3. Toxicol. Appl. Pharmacol. v.32 no.587 Alteration of induced cellular and humoral immune responses by pesticides and chemicals of environmental concern: Quantitative studies of immunosuppression by DDT, Arclor 1254, Carbaryl, Carbofuran, and Methylparathion Street, J.C.;Sharma, R.P.
  4. Pest. Biochem. Physiol. v.26 no.353 Evaluation of pesticide effects on humoral response to sheep erythrocytes and mouse hepatitis virus 3 by immunosorbent analysis Fornier, M.;Bernier, J.;Flipo, D.;Krzystyniak, K.
  5. J. Envir. Path. Toxic. v.4 no.53 Immunocompetence over the lifespan of mice exposed in utero to carbofuran or diazinon. Ⅰ. Changes in serum immunoglobulin concen-tration Barnett, J.B.;Spyker-Crammer, J.M.;Avery, D.L.;Hoberman, A.M.
  6. Mol. Toxicol. v.1 no.2-3 Macrophage functional activities versus cellular parameters upon sublethal pesticide exposure in mice Krzystyniak, K.;Trottier, B.;Jolicoeur, P.;Fournier, M.
  7. Immunopharmacol. Immunotoxicol. v.15 no.2-3 Inhibition of interleukin-2 driven proliferation of mouse CTLL-2 cells, by selected carbamate and organophosphate insecticides nad congeners of carbaryl George P.C.;Vennerstrom, J.L.;Bavari, S.;Wang, T.I.
  8. Pharmacol. Res. v.33 no.4-5 Antagonism produced by hypertonic nutrient solutions on the depressive effect of carbofuran on isolated guinea pig atria Nascimento, D.C.;Sakate, M.
  9. Arch Toxicol. v.65 no.4 Carbofuran-induced alterations(in vivo) in high-energy phosphates, creatine kinase(CK) and CK isoenzymes Gupta, R.C.;Goad, J.T.;Kadel, W.L.
  10. J. Cardiovasc. Pharmacol. v.16 no.853 Profile of cromakalim in the treatment of myocardial ischemia in isolated rat hearts and anesthetized dogs Grover, G.J.;Dzwonczy, S.;Parham, C.S.
  11. J. Mol. Cell. Cardiol. v.32 no.21 Ischemia-induced and reperfusion-induced arrhythmias differ in their sensi-tivity to potassium: implications for mechanisms of initiation and maintenance of ventricular fibrillation Curtis, M.J.;Hearse, D.J.
  12. Am. Fam. Physician v.47 no.1613 Choninesterase-inhibiting insecticide toxicity Fuortes, L.J.;Ayebo, A.D.;Kross, B.C.
  13. Environ. Health Perspect. v.72 no.267 The toxicological effects of the carbamate insecticide aldicarb in mammals: a review Risher, J.F.;Mink, E.L.;Stara, J.F.
  14. Eur. J. Pharmacol. v.361 no.61 Pressor and bradycardiac effects of tacrine and other acetylcholinesterase inhibitors inn the rat Lazartigues E.;Freslon, J-L;Tellioglu, T.;Courbon, B.;Pelat, M.;Trau, M.-A.;Montastruc, J.-L.;Rascol. O.