약학회지 (YAKHAK HOEJI)

  • 제45권6호
  • /
  • Pages.582-587
  • /
  • 2001
  • /
  • 0377-9556(pISSN)
  • /
  • 2383-9457(eISSN)
대한약학회 (The Pharmaceutical Society of Korea)
권호 표지

(S)-5-요오드 -2-아미노인단.염산염의 합성

Synthesis of (S)-5-iodo-2-aminoindan.HCI

  • 마은숙 (대구카톨릭대학교 약학대학)
  • 발행 : 2001.12.01
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초록

(S)-5-iodo-2-aminoindan.HCI (7) was synthesized for developing a serotonergic agent. (S)- Phenylalanine was protected with trifuoroacetyl group and compound 2 was prepared by direct iodination in acetic acid and in the presence of I$_2$, KIO$_4$, and sulfuric acid. Compound 3 was cyclized by Friedel-Crafts reaction and reduced with NaBH$_4$ to form 5-iodo-2-(N-trifluoroacetyl)aminoindan-1-ol (4) . This compound was reduced to indan derivative 5 using the triethylsilane and BF$_3$ . Et$_2$O. It was basified with $K_2$CO$_3$ solution and treated with saturated HCl in ethyl ether to isolate compound 7.

키워드

참고문헌

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