Food Science and Preservation (한국식품저장유통학회지)
- Volume 8 Issue 1
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- Pages.109-117
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- 2001
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- 3022-5477(pISSN)
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- 3022-5485(eISSN)
Antioxidative and Antimutagenic Effects of the Ethanol Elrtract from Cordyceps militaris
번데기동충하초(Cordyceps militaris) 에탄을 추출물의 항산화성 및 항돌연변이원성 효과
Abstract
Cordyceps militaris is a parasitic fungus that has been used as a Chinese medicine for the treatment of fatigue, debility, kidney disease, tuberculosis, asthma and cardiac insufficiency etc. This study was carried out to determine the antioxidative and antimutagenic effects of Cordyceps militaris using DPPH free radical donating method and Ames test, respectively. They were extracted with ethanol and then further fractionated to n-hexane, chloroform, ethyl acetate, butanol and water, stepwise. Among five fractions, the EtOAc and BuOH fractions showed the highest electron donating activities, about 2-fold higher than other fractions. In Ames test, most of the extracts had strong antimutagenic effects against the mutagenesis induced by N-methyl-N'-nitro-N-nitrosoguanidine(MNNG), 4-nitroquinoline-1-oxide(4NQO), benzo(
번데기동충하초(Cordyceps militaris(L. ex fr.) Link)의 수소전자공여능 및 항돌연변이원성을 살펴본 결과 부탄을 분획물과 에틸 아세테이트 분획물에서 수소전자공여능이 다른 시료에 비해 2배 이상 높게 나타났다. 항돌연변이원성 실험결과에서는 직접변이원인 MNNG, 4NQO 그리고 간접변이원인 B(