Korean Journal of Veterinary Pathology (한국수의병리학회지)

Korean Society of Veterinary Pathology (한국수의병리학회)
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The Chemopreventive Effect of Sodium Selenite on Colon Carcinogenesis in Medium-Term Multi-Organ Bioassay

다장기 중기발암성 시험법을 이용한 셀렌염의 대장암 억제효과에 대한 연구

  • Han, Beom-Seok (General Toxicology Department, National Institute of Toxicological Research, KFDA) ;
  • Hong, Choong-Man (General Toxicology Department, National Institute of Toxicological Research, KFDA) ;
  • Shin, Dong-Hwan (General Toxicology Department, National Institute of Toxicological Research, KFDA) ;
  • Lee, Kook-Kyung (General Toxicology Department, National Institute of Toxicological Research, KFDA) ;
  • Ahn, Byeong-Woo (General Toxicology Department, National Institute of Toxicological Research, KFDA) ;
  • Jang, Dong-Deuk (General Toxicology Department, National Institute of Toxicological Research, KFDA)
  • 한범석 (국립독성연구소 일반독성부) ;
  • 홍충만 (국립독성연구소 일반독성부) ;
  • 신동환 (국립독성연구소 일반독성부) ;
  • 이국경 (국립독성연구소 일반독성부) ;
  • 안병우 (국립독성연구소 일반독성부) ;
  • 장동덕 (국립독성연구소 일반독성부)
  • Published : 2001.06.01
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Abstract

This study was conducted to assess the chemopreventive effects of sodium selenite in the rat medium-term multi-organ bioassay using a DMBDD model (DEN+MNU+BBN+DMH+DHPN). Seventy five,6-week-old, male SD rats were divided into 3 groups. The animals in group 1 received DEN(diethylnitrosamine,100 mg/kg bw, single i.p., in saline), MNU (N-methyl-nitrosourea,20 mg/kg bw, i.p.,4 times for 2 weeks), BBN (N-butyl-N-(4-hydroxybutyl) nitrosamine, 0.2% in drinking water for 2 weeks), DMH (1,2-dimethylhydrazine, 40 mg/kg bw, s.c., in saline.4 times (or 2 weeds), and DHPN (N-bis(2-hydroxy-pro-pal)nitrosamine,0.1% in drinking water for 2 weeks), then were placed on sodium selenite (4 ppm in drinking water) for 22 weeks from weeks 4 to 26. The animals in group 2 were given DMBDD alone. The animals in group 3 were given sodium selenite alone. Animals were sacrificed at week 12 for ACF quantitative analysis and at week 26 for tumor induction. The body weights in the group 1 were significantly decreased compared with those of group 2. The tumor multiplicities of large intestine in the group 1 were significantly decreased compared with those of group 2 (P<0.05). These results indicate that sodium selenite may have a potential as chemopreventive agents of colon carcinogenesis.

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