Influence of Cromakalim, $K^+$Channel Opener, and Glibenclamide, $K^+$ Channel Blocker, on Intestinal Movements in Rabbit

토끼의 장운동에 미치는 $K^+$Channel 개방제인 Cromakalim과 $K^+$Channel 차단제인 Glibenclamide의 영향

This study was attempted to investigate the effects of cromakalim (CRK), $K^{+}$ channel opener, and glibenclamide (GLY), $K^{+}$ channel blocker, on intestinal function of rabbit. CRK supressed the tension and spontaneous movement of intestinal strips. CRK enhanced the tension and spontaneous movement of strips induced by acetylcholine. Also the inhibiting effect of dopamine was potentiated by CRK. GLY augmented the tension, but did not affect the spontaneous movement of strips. GLY inhibited tension and spontaneous movements in intestinal strips induced by acetylcholine, GLY blocked the dopamine-induced attenuation of tension, but not the decrease of spontaneous movements in intestinal strips. The present studies suggest that $K^{+}$ channel opening suppresses intestinal movements, whereas it's blockade enhances intestinal movements in rabbit.abbit.