Biomolecules & Therapeutics
- Volume 9 Issue 2
- /
- Pages.112-118
- /
- 2001
- /
- 1976-9148(pISSN)
- /
- 2005-4483(eISSN)
Effects of Malloti Cortex Water Extract, Bergenin, and Acetylbergenin on Liver Fibrosis Induced by Bile Duct Ligation in Rats
- Chung, Myeon-Woo (College of Pharmacy, Chungbuk National University) ;
- Sunoo, Sub (College of Pharmacy, Chungbuk National University) ;
- Kim, Seung-Hwan (College of Physical Education, Kyunghee National University) ;
- Kim, Hack-Seang (College of Physical Education, Kyunghee National University)
- Published : 2001.06.01
Abstract
The effects of Malloti Cortex Water Extract (MCWE), bergenin (isolated as an active component from MCWE), and acetylbergenin (synthesized from acetylation of bergenin) on the liver fibrosis induced by bile duct ligation (BDL) in rats. We studied hydroxypro1ine (HYP) as a marker of collagen accumulation in the liver, alanine aminotransferase (s-ALT), aspartate aminotransferase (s-AST), and alkaline phosphatase (s-ALP) as serum markers of liver cell damage induced by BDL, MCWE, bergenin, and acetylbergenin decreased towards normal the accumulated levels of HYP in the liver and the elevated serum levels of s-ALT, s-AST and 5-ALP. The results indicate that MCWE, bergenin, and acetylbergenin ameliorated the liver damage induced by BDL in rats.