General Pharmacology of (R)-JG-381, A New Antidiabetic Agent

항당뇨물질 (R)-JG-381의 일반약리작용

  • 오우용 (성균관대학교 약학대학) ;
  • 이상호 (성균관대학교 약학대학) ;
  • 주상섭 (서울대학교 약학대학) ;
  • 박형근 (서울대학교 약학대학) ;
  • 함광수 ((주)태평양제약 중앙연구소) ;
  • 조장섭 ((주)태평양제약 중앙연구소) ;
  • 이선미 (성균관대학교 약학대학)
  • Published : 2001.03.01

Abstract

General pharmacological properties of (R)-JG-381 were examined in laboratory animals to investigate its safety profile. Administration of (R)-JG-381 (50 and 100 mg/kg) in mice and rats had no effects of general behaviors, central nervous system of the animals in test systems of pentobarbital-induced sleeping time, writhing syndromes induced by 0.7% acetic acid, chemo-shock produced by pentylenetetrazole, and, however, had mild effects on motor coordination. Heart rate and blood pressure were not changed by (R)-JG-381 treatment. (R)-JG-381 also showed mild effects on intestinal propulsion and gastric secretion. These results suggest that (R)-JG-381 dose not exert serious pharmacological effects.

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